Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

doi:10.3748/wjg.v20.i29.10158

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 20, Issue 29

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (8347)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-5) series.

Item

Count

PDF

633

WORD

315

HTML

4734

Figures (1-3)

270

Tables (1-5)

192

Sum=6144

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1103

Download

1100

Sum=2203

Aug 7, 2014 (publication date) through Dec 24, 2024

Times Cited of This Article

Times Cited (59)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Gastroenterol. Aug 7, 2014; 20(29): 10158-10165
Published online Aug 7, 2014. doi: 10.3748/wjg.v20.i29.10158

Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

Sami Akbulut, Hulya Elbe, Cengiz Eris, Zumrut Dogan, Gulten Toprak, Emrah Otan, Erman Erdemli, Yusuf Turkoz

Sami Akbulut, Cengiz Eris, Emrah Otan, Liver Transplant Institute, Inonu University Faculty of Medicine, 44280 Malatya, Turkey

Hulya Elbe, Department of Histology and Embriology, Inonu University Faculty of Medicine, 44280 Malatya, Turkey

Zumrut Dogan, Department of Anatomy, Adiyaman University Faculty of Medicine, 02100 Adiyaman, Turkey

Gulten Toprak, Department of Biochemistry, Dicle University Faculty of Medicine, 21280 Diyarbakir, Turkey

Erman Erdemli, Yusuf Turkoz, Department of Biochemistry, Inonu University Faculty of Medicine, 44280 Malatya, Turkey

Author contributions: Akbulut S, Eris C, Dogan Z and Erdemli E performed all of experimental design and surgical procedures; Akbulut S, Elbe H and Otan E contributed to writing the paper and review of the literature; Elbe H provided histopathologic information and performed statistical analysis; Toprak G and Turkoz Y provided biochemical information.

Correspondence to: Sami Akbulut, Assistant Professor, FICS, FACS, Liver Transplant Institute, Inonu University Faculty of Medicine, 44280 Malatya, Turkey. akbulutsami@gmail.com

Telephone: +90-422-3410660 Fax: +90-422-3410036

Received: December 9, 2013
Revised: February 11, 2014
Accepted: April 8, 2014
Published online: August 7, 2014
Processing time: 240 Days and 16.2 Hours

Core Tip

Core tip: While the underlying mechanism of methotrexate (MTX)-induced hepatotoxicity remains to be fully elucidated, increases in oxidative stress have been linked to the effects of MTX; moreover, MTX-induced toxicity has been shown to be associated with increases in lipid peroxidation in various tissues, such as liver, using rat model systems. A few previous studies have shown that prophylactic delivery of antioxidant agents can prevent MTX-induced hepatotoxicity. Based on this information, we aimed to investigate the role of oxidative stress in MTX-induced hepatotoxicity and to evaluate the potential therapeutic effects of the cytoprotective antioxidants N-acetylcysteine, amifostine, and ascorbic acid.