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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2014; 20(28): 9506-9512
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9506
Published online Jul 28, 2014. doi: 10.3748/wjg.v20.i28.9506
Conventional, but not remote ischemic preconditioning, reduces iNOS transcription in liver ischemia/reperfusion
Bergthor Björnsson, Anders Winbladh, Per Gullstrand, Per Sandström, Department of Surgery, County Council of Östergötland, 581 85 Linköping, Sweden
Bergthor Björnsson, Anders Winbladh, Linda Bojmar, Tommy Sundqvist, Per Gullstrand, Per Sandström, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, 581 85 Linköping, Sweden
Author contributions: All authors participated in designing the research; Björnsson B, Winbladh A and Bojmar L performed the research; all authors contributed to the interpretation of the results and writing the paper.
Supported by Gösta Milton Donation Fund (Partly)
Correspondence to: Bergthor Björnsson, MD, Department of Surgery, County Council of Östergötland, 581 85 Linköping, Sweden. bergthor.bjornsson@lio.se
Telephone: +46-10-1030000 Fax: +46-10-1033570
Received: February 12, 2014
Revised: April 12, 2014
Accepted: May 23, 2014
Published online: July 28, 2014
Processing time: 164 Days and 9.7 Hours
Revised: April 12, 2014
Accepted: May 23, 2014
Published online: July 28, 2014
Processing time: 164 Days and 9.7 Hours
Core Tip
Core tip: Ischemic preconditioning has been shown to reduce ischemia/reperfusion injury (IRI) in the liver. NO has been shown to be important in the preconditioning process as well as in IRI. This study shows that ischemic preconditioning (IPC) but not remote ischemic preconditioning (R-IPC) reduces inducible nitric oxide synthase and interleukin 1 receptor transcription during early reperfusion. As it has been shown that IPC protects the liver more than R-IPC, this reduction in inflammatory activation may be important. In addition, this study shows that nitrite and nitrate are consumed in the liver during ischemia, unlike the levels in peripheral blood.