Alvares-da-Silva MR, Oliveira CPMS, Stefano JT, Barbeiro HV, Barbeiro D, Soriano FG, Farias AQ, Carrilho FJ, D’Albuquerque LAC. Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation. World J Gastroenterol 2014; 20(26): 8667-8673 [PMID: 25024624 DOI: 10.3748/wjg.v20.i26.8667]
Corresponding Author of This Article
Mario Reis Alvares-da-Silva, MD, PhD, Division of Gastroenterology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcellos, 2350, sala 2033, 90035-903 Porto Alegre, Brazil. marioreis@live.com
Research Domain of This Article
Transplantation
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 14, 2014; 20(26): 8667-8673 Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8667
Pro-atherosclerotic markers and cardiovascular risk factors one year after liver transplantation
Mario Reis Alvares-da-Silva, Claudia Pinto Marques Souza de Oliveira, José Tadeu Stefano, Hermes V Barbeiro, Denise Barbeiro, Francisco G Soriano, Alberto Queiroz Farias, Flair José Carrilho, Luiz Augusto Carneiro D’Albuquerque
Mario Reis Alvares-da-Silva, Luiz Augusto Carneiro D’Albuquerque, Division of Liver and Gastrointestinal Transplant (LIM-37), Department of Gastroenterology, University of São Paulo School of Medicine, 05508-070 São Paulo, Brazil
Mario Reis Alvares-da-Silva, Division of Gastroenterology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcellos, 90035-903 Porto Alegre, Brazil
Claudia Pinto Marques Souza de Oliveira, José Tadeu Stefano, Alberto Queiroz Farias, Flair José Carrilho, Division of Clinical (LIM-07), Department of Gastroenterology, University of São Paulo School of Medicine, 05508-070 São Paulo, Brazil
Hermes V Barbeiro, Denise Barbeiro, Francisco G Soriano, Division of Emergency Medicine (LIM-51), University of São Paulo School of Medicine, 05508-070 São Paulo, Brazil
Author contributions: Alvares-da-Silva MR and Oliveira CPMS designed the study, collected the data and performed and co-wrote the manuscript; Stefano JT provided and coordinated the collection of all the human materials; Barbeiro HV, Barbeiro D and Soriano FG performed most of the laboratory analyses; Farias AQ coordinated the collection of all the human materials; Carrilho FJ and Carneiro D’Albuquerque LA co-designed the study, and provided financial support for this work; all co-authors reviewed and approved the final manuscript.
Supported by Department of Gastroenterology LIM-37/LIM07, School of Medicine, University of São Paulo, Brazil
Correspondence to: Mario Reis Alvares-da-Silva, MD, PhD, Division of Gastroenterology, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcellos, 2350, sala 2033, 90035-903 Porto Alegre, Brazil. marioreis@live.com
Telephone: +55-51-33598307 Fax: +55-51-33598307
Received: January 30, 2014 Revised: March 18, 2014 Accepted: April 15, 2014 Published online: July 14, 2014 Processing time: 191 Days and 19.7 Hours
Core Tip
Core tip: Liver transplant (LT) patients a have high risk of long-term development of cardiovascular disease (CVD), which is currently recognized as an important cause of death 5 to 10 years after transplant in this population. Atherosclerosis is a hallmark of CVD, with both disorders involving a prolonged asymptomatic phase and often leading to morbidity and mortality upon initial clinical presentation. Regardless, endothelial dysfunction is the first step in developing early atherosclerosis. In the present study, we evaluated inflammatory and endothelial markers one year after transplantation in asymptomatic LT recipients in comparison to high-CVD-risk biopsy-proven nonalcoholic steatohepatitis (NASH) patients and healthy controls. We found that LT recipients had pro-inflammatory profiles and endothelial dysfunction similar to those of NASH patients, both of which were higher than those in the compared controls. These findings suggest that LT recipients, even in a short 1-year follow-up period, display a high atherosclerotic risk and should be carefully monitored to effectively prevent CVD.
