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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2014; 20(26): 8660-8666
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8660
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8660
Outcomes of autologous bone marrow mononuclear cell transplantation in decompensated liver cirrhosis
Yang-Qiu Bai, Yu-Xiu Yang, Song-Ze Ding, Ming-Bo Cao, Yan-Rui Zhang, Bing-Yong Zhang, Department of Gastroenterology and Hepatology, Zhengzhou University People’s Hospital, Zhengzhou 450003, Henan Province, China
Ya-Ge Yang, Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450003, Henan Province, China
Fang-Li Jin, The Seventh People’s Hospital of Zhengzhou City, Zhengzhou 450006, Henan Province, China
Author contributions: Yang YX and Zhang BY designed the experiment; Bai YQ, Yang YG and Jin FL performed the experiments; Bai YQ and Yang YG wrote the manuscript; Cao MB and Zhang YR coordinated the study; Ding SZ revised the manuscript.
Supported by Grants for Key Bio-Medical Research Projects in Henan Province, China, No. 2011020122, No. 112102310251
Correspondence to: Bing-Yong Zhang, MD, PhD, Department of Gastroenterology and Hepatology, Zhengzhou University People’s Hospital, No. 7 Wei Wu Road, Zhengzhou 450003, Henan Province, China. zhbingyong@sina.com.cn
Telephone: +86-371-65897728 Fax: +86-371-65964376
Received: January 27, 2014
Revised: April 10, 2014
Accepted: May 12, 2014
Published online: July 14, 2014
Processing time: 167 Days and 18.8 Hours
Revised: April 10, 2014
Accepted: May 12, 2014
Published online: July 14, 2014
Processing time: 167 Days and 18.8 Hours
Core Tip
Core tip: We aimed to study the efficacy of autologous bone marrow mononuclear cells (BM-MNCs) transplantation in terms of improving liver function and reducing complications in patients with decompensated cirrhosis. Liver function parameters were improved one month after BM-MNCs transfusion in cirrhosis patients, firstly in prealbumin level, followed by albumin level, total bilirubin, prothrombin time, prothrombin activity, fibrinogen and platelet count. The efficacy of BM-MNCs transplantation lasted 3-12 mo as compared with the control group. However, these improvements disappeared 24 mo after transplantation.