Clinical Trials Study
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World J Gastroenterol. Jul 14, 2014; 20(26): 8653-8659
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8653
Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy
Hong Ma, Ayshamgul Hasim, Batur Mamtimin, Bin Kong, Hai-Ping Zhang, Ilyar Sheyhidin
Hong Ma, Hai-Ping Zhang, Ilyar Sheyhidin, Department of Thoracic Surgery, The First Affiliated Hospital, Medical University of Xinjiang, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China
Hong Ma, Ayshamgul Hasim, Department of Pathology, College of Basic Medicine, Medical University of Xinjiang, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China
Batur Mamtimin, Centers of Pharmaceutical Analysis, College of Pharmacy, Medical University of Xinjiang, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China
Bin Kong, Pharmacy Department of Production and Construction Corps General Hospital of Xinjiang, Urumqi 830011, Xinjiang Uyghur Autonomous Region, China
Author contributions: Ma H and Hasim A contributed equally to this work; Ma H and Sheyhidin I designed the research; Kong B performed the experiments; Mamtimin B analyzed the data; Zhang HP collected plasma samples; and Ma H wrote the manuscript.
Supported by National Natural Science Foundation of China, Grant No. 81360356; and Scientific Research Foundation of Xinjiang Medical University, Grant No. XJC201221
Correspondence to: Ilyar Sheyhidin, Professor, Department of Thoracic Surgery, The First Affiliated Hospital, Medical University of Xinjiang, 137 Liyushan Road, Urumqi 830054, Xinjiang Uyghur Autonomous Region, China. ilyarsha@hotmail.com
Telephone: +86-991-4366286 Fax: +86-991-4366286
Received: January 27, 2014
Revised: March 17, 2014
Accepted: April 27, 2014
Published online: July 14, 2014
Processing time: 168 Days and 15.4 Hours
Core Tip

Core tip: Recently, metabolomics-based techniques have been developed to identify cancer-related metabolic signatures for early cancer detection. However, studies on esophageal squamous cell carcinoma (ESCC) remain limited. This study used high-performance liquid chromatography to quantitatively study plasma free amino acid (PFAA) changes in ESCC patient, and analyze the correlation between PFAA profiles and clinicopathological characteristics of ESCC. The results showed that most of the amino acids were differentially expressed in ESCC patients and control subjects, and were related to the ESCC clinicopathological characteristics. The study suggests that PFAA profiling is of potential value for screening or diagnosing ESCC.