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World J Gastroenterol. Jul 7, 2014; 20(25): 7993-8004
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.7993
Published online Jul 7, 2014. doi: 10.3748/wjg.v20.i25.7993
Prospects for inhibiting the post-transcriptional regulation of gene expression in hepatitis B virus
Augustine Chen, Centre for Translational Cancer Research, Department of Biochemistry, University of Otago, 710 Cumberland St, Dunedin 9054, New Zealand
Nattanan Panjaworayan T-Thienprasert, Department of Biochemistry, Faculty of Science, Kasetsart University, Ladyaow Chatuchak, Bangkok 10900, Thailand
Chris M Brown, Department of Biochemistry and Webster Centre for Infectious diseases, University of Otago, 710 Cumberland St, Dunedin 9054, New Zealand
Author contributions: All authors contributed equally to writing this review.
Supported by Thailand Research Fund and the Commission on Higher Education Fund grant (to Nattanan Panjaworayan T-Thienprasert), No. MRG5680051; and NZ Health Research Council Grant 05/195 (to Augustine Chen and Chris M Brown)
Correspondence to: Chris M Brown, PhD, Department of Biochemistry and Webster Centre for Infectious diseases, University of Otago, 710 Cumberland St, Dunedin 9054, New Zealand. chris.brown@otago.ac.nz
Telephone: +64-3-4795201 Fax: +64-3-4797866
Received: October 25, 2013
Revised: January 19, 2014
Accepted: April 8, 2014
Published online: July 7, 2014
Processing time: 251 Days and 4.7 Hours
Revised: January 19, 2014
Accepted: April 8, 2014
Published online: July 7, 2014
Processing time: 251 Days and 4.7 Hours
Core Tip
Core tip: This review presents an outline of what is known about post-transcriptional regulation of gene expression in hepatitis B virus, a virus that infects over 200 million people worldwide. These steps may be targeted by novel antivirals, or be considered when characterising new antivirals derived from screening natural or synthetic products.