Meta-Analysis
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World J Gastroenterol. Jun 14, 2014; 20(22): 7040-7048
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.7040
Placement of prophylactic pancreatic stents to prevent post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: A meta-analysis
Qing-Qing Shi, Xiao-Yi Ning, Ling-Ling Zhan, Guo-Du Tang, Xiao-Ping Lv
Qing-Qing Shi, Guo-Du Tang, Xiao-Ping Lv, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Xiao-Yi Ning, Department of Hematology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Ling-Ling Zhan, Department of Clinical Experimental Medicine, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Lv XP and Tang GD designed the study; Lv XP and Zhang LL carried out critical appraisal of the included studies; Shi QQ and Ning XY performed the literature search, extracted the data, and assisted in critical appraisal of the included studies; Shi QQ wrote the manuscript; Lv XP and Zhang LL helped to revise the manuscript; all authors critically reviewed the manuscript and approved this version to be published.
Supported by The Natural Science Foundation of Guangxi Zhuang Autonomous Region, China, No. 2012GXNSFAA053143 and No. 1355005-3-2
Correspondence to: Xiao-Ping Lv, Professor, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Shuangyong Road No.6, Nanning 530021, Guangxi Zhuang Autonomous Region, China. lxxp58@hotmail.com
Telephone: +86-771-3277211 Fax: + 86-771-3277285
Received: October 23, 2013
Revised: January 10, 2014
Accepted: March 5, 2014
Published online: June 14, 2014
Processing time: 235 Days and 19.5 Hours
Core Tip

Core tip: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is the most common and serious complication of ERCP. In the past few decades, a number of clinical randomized controlled trials have shown that pancreatic stents can effectively prevent the occurrence of post-ERCP pancreatitis (PEP). In view of these high quality data, we conducted this meta-analysis to evaluate the effectiveness of pancreatic stent placement in preventing PEP in high-risk patients. Our results supported that pancreatic stent placement is an effective means to prevent PEP and alleviate the severity (mild and moderate) of PEP in high-risk patients. Furthermore, no serious complications were reported in subjects in the stent group.