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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 28, 2014; 20(20): 6123-6132
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6123
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6123
Clinicopathological utility of sialoglycoconjugates in diagnosing and treating colorectal cancer
Yoshinori Inagaki, Jianjun Gao, Peipei Song, Norihiro Kokudo, Wei Tang, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan
Munehiro Nakata, Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa 259-1292, Japan
Author contributions: Inagaki Y drafted the manuscript; Gao J and Song P did literature search and contributed to critical revision of intellectual content; Kokudo N, Nakata M and Tang W revised the manuscript and provided important suggestions; all authors reviewed and approved the final revised version.
Correspondence to: Wei Tang, MD, PhD, Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. tang-sur@h.u-tokyo.ac.jp
Telephone: +81-3-58009269 Fax: +81-3-56843989
Received: September 27, 2013
Revised: November 30, 2013
Accepted: February 16, 2014
Published online: May 28, 2014
Processing time: 243 Days and 0.5 Hours
Revised: November 30, 2013
Accepted: February 16, 2014
Published online: May 28, 2014
Processing time: 243 Days and 0.5 Hours
Core Tip
Core tip: Many types of cancer-associated sialoglycoconjugates are produced during oncogenesis or in various stages of malignant transformation. Aberrant expression of sialoglycoconjugates has been evaluated in many histochemical and molecular biological studies. An overview of the current knowledge is crucial to understand its clinicopathological utility in diagnosing and treating colorectal cancer. The biological significance of sialoglycoconjugates in the progression of cancer is also discussed. This review may contribute to expanding the use of cancer-associated sialoglycoconjugates in cancer diagnosis and therapy.