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World J Gastroenterol. May 28, 2014; 20(20): 5999-6005
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.5999
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.5999
Significance of viral status on occurrence of hepatitis B-related hepatocellular carcinoma
Li-Shuai Qu, Guo-Xiong Zhou, Department of Gastroenterology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China
Author contributions: Qu LS wrote the initial draft of the manuscript; Zhou GX contributed to the conception and design of the review and supervised the review.
Supported by China Ministry of Health, No. W201202; Natural Science Foundation of Jiangsu Province, No. BK2012225; Foundation of Jiangsu Province, No. WS056; National Nature Science Foundation of China, No. 81302056
Correspondence to: Guo-Xiong Zhou, Professor, Department of Gastroenterology, Affiliated Hospital of Nantong University, No. 20 Xisi Road, Nantong 226001, Jiangsu Province, China. guoxiongzhou@yeah.net
Telephone: +86-513-81161826 Fax: +86-513-85519820
Received: September 15, 2013
Revised: November 3, 2013
Accepted: January 3, 2014
Published online: May 28, 2014
Processing time: 254 Days and 15.4 Hours
Revised: November 3, 2013
Accepted: January 3, 2014
Published online: May 28, 2014
Processing time: 254 Days and 15.4 Hours
Core Tip
Core tip: There are conflicting data on the relationship between hepatitis B virus infection risk factors and hepatocarcinogenesis. In this article, we reviewed the risk of hepatitis B surface antigen level, seropositivity of hepatitis B e antigen, high viral load, viral genotype, and specific viral sequence mutations, separately.