Original Article
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World J Gastroenterol. Apr 14, 2014; 20(14): 4001-4010
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.4001
Epithelial membrane protein 1 negatively regulates cell growth and metastasis in colorectal carcinoma
Guo-Gui Sun, Ya-Di Wang, Da-Wei Cui, Yun-Jie Cheng, Wan-Ning Hu
Guo-Gui Sun, Wan-Ning Hu, Department of Chemoradiotherapy, Tangshan People’s Hospital, Tangshan 063000, Hebei Province, China
Ya-Di Wang, Department of Radiotherapy, the Military General Hospital of Beijing PLA, Beijing 100700, China
Da-Wei Cui, Department of Urology, Tangshan Workers Hospital, Tangshan 063000, Hebei Province, China
Yun-Jie Cheng, Department of Radiotherapy, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, Hebei Province, China
Author contributions: Sun GG and Wang YD performed the majority of experiments; Cui DW and Cheng YJ provided vital reagents and analytical tools and were also involved in editing the manuscript; Hu WN designed the study and wrote the manuscript.
Correspondence to: Dr. Wan-Ning Hu, Department of Chemoradiotherapy, Tangshan People’s Hospital, No. 65, Shengli Road, Lunan District, Tangshan 063000, Hebei Province, China. wanning_hu2008@sina.com
Telephone: +86-315-2880376 Fax: +86-315-2880376
Received: September 13, 2013
Revised: December 24, 2013
Accepted: February 17, 2014
Published online: April 14, 2014
Processing time: 212 Days and 14.5 Hours
Core Tip

Core tip: Epithelial membrane protein 1 (EMP1) has a known role in tumor development and progression, and its activity is linked to a number of biological processes including proliferation, apoptosis, invasion, and metastasis of colorectal cancer. We detected expression of EMP1 in colorectal carcinoma and analyzed the biological effect of EMP1 overexpression in a colorectal carcinoma cell line. EMP1 expression was decreased in colorectal cancer and its expression correlated significantly with T stage, lymph node metastasis, clinic stage, histological grade, and poor overall survival. Taken together, our findings suggest that EMP1 may play an important role as a negative regulator of colorectal cancer.