Topic Highlight
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World J Gastroenterol. Apr 14, 2014; 20(14): 3927-3937
Published online Apr 14, 2014. doi: 10.3748/wjg.v20.i14.3927
An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa
Hiroyuki Yamamoto, Yoshiyuki Watanabe, Tadateru Maehata, Ryo Morita, Yoshihito Yoshida, Ritsuko Oikawa, Shinya Ishigooka, Shun-ichiro Ozawa, Yasumasa Matsuo, Kosuke Hosoya, Masaki Yamashita, Hiroaki Taniguchi, Katsuhiko Nosho, Hiromu Suzuki, Hiroshi Yasuda, Yasuhisa Shinomura, Fumio Itoh
Hiroyuki Yamamoto, Yoshiyuki Watanabe, Tadateru Maehata, Ryo Morita, Yoshihito Yoshida, Ritsuko Oikawa, Shinya Ishigooka, Shun-ichiro Ozawa, Yasumasa Matsuo, Kosuke Hosoya, Masaki Yamashita, Hiroshi Yasuda, Fumio Itoh, Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki 216-8511, Japan
Hiroaki Taniguchi, Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
Katsuhiko Nosho, Yasuhisa Shinomura, Department of Gastroenterology, Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan
Hiromu Suzuki, Department of Molecular Biology, Sapporo Medical University School of Medicine, Sapporo 060-8556, Japan
Author contributions: Yamamoto H conceived the topic, reviewed the literature, and prepared the manuscript; Watanabe Y, Maehata T, Morita R, Yoshida Y, Oikawa R, Ishigooka S, Ozawa S, Matsuo Y, Hosoya K, Yamashita M, Taniguchi H, Nosho K, and Suzuki H reviewed and analyzed the literature; Yasuda H, Shinomura Y and Itoh F provided intellectual support.
Supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan
Correspondence to: Hiroyuki Yamamoto, MD, FJSIM, PhD, Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Sugo 2-16-1 Miyamae, Kawasaki 216-8511, Japan. h-yama@marianna-u.ac.jp
Telephone: +81-44-9778111 Fax: +81-44-9762282
Received: October 28, 2013
Revised: January 13, 2014
Accepted: March 7, 2014
Published online: April 14, 2014
Processing time: 167 Days and 16.2 Hours
Core Tip

Core tip: The genetic and epigenetic alterations in gastric cancers (GC) have biological and clinical implications. Recent advances in the molecular research of GC have introduced new diagnostic and therapeutic strategies to clinical settings. In this review, we summarize the key findings of past reports pertaining to the genetics and epigenetics of GC and their relationship to and future applications in next-generation sequencing (NGS). We also describe the recurrently mutated genes and alterations in GC identified by NGS technology and discuss the basic framework for future investigations, including the challenges of using NGS as a tool for biomarker and therapeutic target discovery.