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World J Gastroenterol. Apr 7, 2014; 20(13): 3418-3430
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3418
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3418
Adaptive immune response during hepatitis C virus infection
Juan Ramón Larrubia, Elia Moreno-Cubero, Megha Uttam Lokhande, Silvia García-Garzón, Alicia Lázaro, Joaquín Miquel, Cristian Perna, Eduardo Sanz-de-Villalobos, Translational Hepatology Unit, Guadalajara University Hospital, University of Alcalá, E-19002 Guadalajara, Spain
Juan Ramón Larrubia, Department of Medicine and Medical Specialities, School of Medicine, University of Alcalá, E-28801 Alcalá de Henares, Spain
Author contributions: Larrubia JR contributed towards the conception and design of the review; Larrubia JR, Moreno-Cubero E and Lokhande MU co-wrote and Larrubia JR revised the manuscript; García-Garzón S, Lázaro A, Miquel J, Perna C and Sanz-de-Villalobos E contributed equally to the supportive work and supervision.
Supported by Grants from “Instituto de Salud Carlos III”, Spain and “European Regional Development Fund (ERDF), a way of making Europe”, E.U., No. PI12/00130; and “Fundación de Investigación Médica Mutua Madrileña”, Spain, No. 8922/2011; and Lokhande MU was funded by a research grant from “Asociación de Hepatología Translacional” No. AHT-2010/01, Spain
Correspondence to: Juan Ramón Larrubia, MD, MSc, PhD, Translational Hepatology Unit, Guadalajara University Hospital, University of Alcalá, Donante de Sangre st, E-19002 Guadalajara, Spain. juan.larrubia@uah.es
Telephone: +34-949-909200 Fax: +34-949-209256
Received: August 21, 2013
Revised: September 28, 2013
Accepted: November 28, 2013
Published online: April 7, 2014
Processing time: 226 Days and 13.8 Hours
Revised: September 28, 2013
Accepted: November 28, 2013
Published online: April 7, 2014
Processing time: 226 Days and 13.8 Hours
Core Tip
Core tip: In the last few years, the knowledge about the role of adaptive immune response in hepatitis C pathogenesis has increased exponentially. This review summarizes our current understanding of the role of antigen-specific responses in hepatitis C virus (HCV) control and liver damage and discusses recent findings that identify costimulatory molecules modulation, apoptosis induction and chemokine regulation as major HCV mechanisms to evade immune control.