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World J Gastroenterol. Dec 28, 2013; 19(48): 9472-9480
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9472
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9472
Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome: A meta-analysis
Shan-Yu Qin, Hai-Xing Jiang, Dong-Hong Lu, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
You Zhou, Minerva Foundation Institute for Medical Research, FI-00290 Helsinki, Finland
Author contributions: Qin SY and Zhou Y conceived the study and implemented the final draft of the manuscript; Jiang HX and Lu DH performed the statistical analysis and wrote the paper; Qin SY and Lu DH searched the studies and extracted the data. All authors read and approved the final manuscript.
Supported by National Natural Science Foundation of China, No. 81260083 and No. 31360221
Correspondence to: Hai-Xing Jiang, PhD, Professor, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China. zhouchin123@163.com
Telephone: +86-0771-5356725 Fax: +86-0771-5356725
Received: July 18, 2013
Revised: September 18, 2013
Accepted: October 19, 2013
Published online: December 28, 2013
Processing time: 180 Days and 2.8 Hours
Revised: September 18, 2013
Accepted: October 19, 2013
Published online: December 28, 2013
Processing time: 180 Days and 2.8 Hours
Core Tip
Core tip: Interleukin-10 (IL-10) polymorphisms have been identified as a biomarker causally associated with occurrence of irritable bowel syndrome (IBS) and receives extensive interest. However, its relationship with IBS remains obscure. In this paper, after combing the data from 8 case-control studies with 928 cases and 1363 controls, the authors found that the IL-10 rs1800870 confers susceptibility to the risk of IBS in Caucasian ethnicity, and the rs1800872 may associate with IBS risk in Asians. However, no significant associations are found between rs1800871 and IBS risk.