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World J Gastroenterol. Dec 28, 2013; 19(48): 9447-9452
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9447
Published online Dec 28, 2013. doi: 10.3748/wjg.v19.i48.9447
Nedaplatin concurrent with three-dimensional conformal radiotherapy for treatment of locally advanced esophageal carcinoma
Ze-Tian Shen, Xin-Hu Wu, Bing Li, Jun-Shu Shen, Zhen Wang, Jing Li, Xi-Xu Zhu, Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China
Author contributions: Shen ZT and Wu XH as co-first authors contributed equally to this study; Zhu XX designed the study and provided financial support for this work; Li B and Shen JS were responsible for the physical planning; Shen ZT, Wu XH, Wang Z and Li J were responsible for clinical observation, follow-up and data analysis; Shen ZT and Wu XH wrote the manuscript; all authors have approved the final article.
Correspondence to: Xi-Xu Zhu, MD, Department of Radiation Oncology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing 210002, Jiangsu Province, China. simon_doctor@163.com
Telephone: +86-25-80860079 Fax: +86-25-80860078
Received: October 13, 2013
Revised: November 20, 2013
Accepted: December 5, 2013
Published online: December 28, 2013
Processing time: 92 Days and 22.9 Hours
Revised: November 20, 2013
Accepted: December 5, 2013
Published online: December 28, 2013
Processing time: 92 Days and 22.9 Hours
Core Tip
Core tip: This paper describes patients with locally advanced esophageal carcinoma who underwent nedaplatin (NDP) concurrent with radiotherapy. The survival and local control as well as the side effects during follow-up were analyzed by comparing with cisplatin (DDP). We found that NDP-based concurrent chemoradiotherapy is effective and well-tolerated. Compared with DDP, NDP-based concurrent chemoradiotherapy exhibits favorable efficacy with lower toxicity.