Kawamura M, Sekine H, Abe S, Shibuya D, Kato K, Masuda T. Clinical significance of white gastric crypt openings observed via magnifying endoscopy. World J Gastroenterol 2013; 19(48): 9392-9398 [PMID: 24409067 DOI: 10.3748/wjg.v19.i48.9392]
Corresponding Author of This Article
Masashi Kawamura, MD, PhD, Department of Gastroenterology, Sendai City Hospital, Shimizukoji, Sendai, Miyagi 984-8501, Japan. dq8m-kwmr@asahi-net.or.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Masashi Kawamura, Hitoshi Sekine, Department of Gastroenterology, Sendai City Hospital, Miyagi 984-8501, Japan
Shu Abe, Department of Gastroenterology, JR Sendai Hospital, Miyagi 980-0022, Japan
Daisuke Shibuya, Katsuaki Kato, Cancer Detection Center, Miyagi Cancer Society, Miyagi 980-0011, Japan
Takayuki Masuda, Division of Pathology, Tohoku University School of Health Sciences, Miyagi 980-8575, Japan
Author contributions: Kawamura M and Sekine H contributed equally to this work; Kawamura M, Sekine H, Abe S, Shibuya D and Kato K designed the research; Kawamura M performed the endoscopic procedures, collected tissue samples, analyzed the data, and wrote the manuscript; Masuda T contributed to the histological analysis.
Correspondence to: Masashi Kawamura, MD, PhD, Department of Gastroenterology, Sendai City Hospital, Shimizukoji, Sendai, Miyagi 984-8501, Japan. dq8m-kwmr@asahi-net.or.jp
Telephone: +81-22-2667111 Fax: +81-22-2118972
Received: August 1, 2013 Revised: October 7, 2013 Accepted: November 3, 2013 Published online: December 28, 2013 Processing time: 166 Days and 3.9 Hours
Core Tip
Core tip: Recent studies have reported that advances in magnifying endoscopy (ME) have led to better correlations between histopathological findings and the ME features of Helicobacter pylori (H. pylori)-induced gastritis. However, the ME findings regarding H. pylori-induced severe inflammation are insufficient. Therefore, we evaluated the relationship between H. pylori-induced gastritis and the whiteness of gastric mucosal crypt openings (COs) in the gastric corpus using ME. Our results showed that mononuclear cell and neutrophil infiltration differed significantly among the CO subtypes. CO whiteness detected via ME was associated with histological evidence of gastritis and helps to predict the severity of inflammation or activity induced by H. pylori in the gastric corpus.
