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World J Gastroenterol. Dec 7, 2013; 19(45): 8408-8419
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8408
Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8408
Proton pump inhibitor for non-erosive reflux disease: A meta-analysis
Ji-Xiang Zhang, Meng-Yao Ji, Jia Song, Hong-Bo Lei, Shi Qiu, Jing Wang, Ming-Hua Ai, Jun Wang, Xiao-Guang Lv, Zi-Rong Yang, Wei-Guo Dong, Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Zhang JX and Dong WG designed the research; Zhang JX, Yang ZR and Lv XG performed the research; Zhang JX, Song J, Qiu S, Ai MH and Wang J analyzed the data; Zhang JX wrote the paper; Yang ZR and Dong WG reviewed and revised the paper.
Correspondence to: Wei-Guo Dong, MD, PhD, Department of Gastroenterology, Renmin Hospital of Wuhan University, Ziyang Road 99, Wuhan 430060, Hubei Province, China. dwg@whu.edu.cn
Telephone: +86-27-88041911 Fax: +86-27-88042292
Received: July 10, 2013
Revised: September 4, 2013
Accepted: September 16, 2013
Published online: December 7, 2013
Processing time: 160 Days and 12.7 Hours
Revised: September 4, 2013
Accepted: September 16, 2013
Published online: December 7, 2013
Processing time: 160 Days and 12.7 Hours
Core Tip
Core tip: As a kind of powerful and effective acid-suppressive drugs, proton pump inhibitor (PPI) has been used for patients with non-erosive reflux disease (NERD), but its efficacy, safety and their influential factors are inconclusive. We performed this systematic review and meta-analysis of randomized controlled trials to assess its efficacy, safety and influential factors. Based on the results of the meta-analysis, we conclude that PPI has a higher symptomatic relief rate and roughly the same adverse rate for NERD. Hiatal hernia and drinking could influence symptomatic relief rate and adverse rate of PPI on NERD.