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World J Gastroenterol. Nov 21, 2013; 19(43): 7726-7734
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7726
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7726
Events associated with apoptotic effect of p-Coumaric acid in HCT-15 colon cancer cells
Saravana Kumar Jaganathan, Eko Supriyanto, IJ N-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia
Saravana Kumar Jaganathan, Department of Research and Development, PSNA College of Engineering and Technology, Dindigul 624622, India
Mahitosh Mandal, School of Medical Science and Technology, Indian Institute of Technology, Kharagpur 721302, West Bengal, India
Author contributions: Jaganathan SK designed and performed the research experiments; Jaganathan SK, Supriyanto E analyzed the data; Jaganathan SK wrote the paper; Mandal M contributed the new reagents for the study; Supriyanto E and Mandal M provided suggestions and edited the paper.
Supported by Universiti Teknologi Malaysia, Malaysia for providing Visiting Research Fellowship
Correspondence to: Dr. Saravana Kumar Jaganathan, IJ N-UTM Cardiovascular Engineering Centre, Faculty of Bioscience and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru 81310, Malaysia. jaganathaniitkgp@gmail.com
Telephone: +91-607-5558548 Fax: +91-607-5558553
Received: May 14, 2013
Revised: July 24, 2013
Accepted: August 20, 2013
Published online: November 21, 2013
Processing time: 217 Days and 19.2 Hours
Revised: July 24, 2013
Accepted: August 20, 2013
Published online: November 21, 2013
Processing time: 217 Days and 19.2 Hours
Core Tip
Core tip: This article describes apoptotic effect of p-Coumaric acid, one of the phenolic components of honey, against colon cancer cells. p-Coumaric acid treatment resulted in the inhibition of proliferation and colony forming ability of human colorectal carcinoma (HCT-15) and HT 29 cells. Major events associated with growth-inhibition are increasing reactive oxygen species generation, increasing lipid layer breaks and a fall in Mitochondrial membrane potential. Further, membrane blebbing and shrinkage of p-Coumaric acid exposed HCT 15 cells insinuated apoptosis. Hence our results depicted that p-Coumaric acid is a prospective candidate for chemoprevention of colon cancer.