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World J Gastroenterol. Nov 14, 2013; 19(42): 7412-7418
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7412
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7412
Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?
Mustafa Cengiz, Seren Ozenirler, Department of Gastroenterology, Gazi University Faculty of Medicine, 06500 Ankara, Turkey
Burcu Aslan Candır, Department of Internal Medicine, Gazi University Faculty of Medicine, 06500 Ankara, Turkey
Güldal Yılmaz, Gülen Akyol, Department of Pathology, Gazi University Faculty of Medicine, 06500 Ankara, Turkey
Author contributions: Cengiz M and Ozenirler S designed the study, contributed to the acquisition of data, and analyzed and interpreted the data; Cengiz M performed the statistical analyses, drafted the article and revised it critically for important intellectual content; Candır BA recruited the patients and contributed to the interpretation of the data; Yılmaz G and Akyol G evaluated the liver histopathology, analyzed the data and contributed to the interpretation of the data.
Correspondence to: Mustafa Cengiz, MD, Department of Gastroenterology, Gazi University Faculty of Medicine, 06500 Ankara, Turkey. drmustafacen@gmail.com
Telephone: +90-312-20227586 Fax: +90-312-2213202
Received: June 9, 2013
Revised: August 19, 2013
Accepted: September 15, 2013
Published online: November 14, 2013
Processing time: 162 Days and 4.7 Hours
Revised: August 19, 2013
Accepted: September 15, 2013
Published online: November 14, 2013
Processing time: 162 Days and 4.7 Hours
Core Tip
Core tip: We evaluated the role of red cell distribution width (RDW) as an indication of nonalcoholic steatohepatitis by comparing the values of biopsy proven non-alcoholic steatohepatitis (NASH) patients with simple steatosis and healthy controls. Independent predictors of the presence of NASH and advanced liver fibrosis were evaluated by using multivariate logistic regression analyses and RDW was a statistically significant independent predictor.