Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats

doi:10.3748/wjg.v19.i38.6416

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2013; 19(38): 6416-6426
Published online Oct 14, 2013. doi: 10.3748/wjg.v19.i38.6416

Diabetic neuropathy: An evaluation of the use of quercetin in the cecum of rats

Paulo Emilio Botura Ferreira, Cláudia Regina Pinheiro Lopes, Angela Maria Pereira Alves, Éder Paulo Belato Alves, David Robert Linden, Jacqueline Nelisis Zanoni, Nilza Cristina Buttow

Paulo Emilio Botura Ferreira, Cláudia Regina Pinheiro Lopes, Angela Maria Pereira Alves, Éder Paulo Belato Alves, Jacqueline Nelisis Zanoni, Nilza Cristina Buttow, Department of Morphological Sciences, Universidade Estadual de Maringá, Maringá, PR. CEP 87020-900, Brazil

David Robert Linden, Department of Physiology and Biomedical Engineering and Enteric NeuroScience Program, Mayo Clinic College of Medicine, Rochester, MN 55905, United States

Author contributions: Ferreira PEB collected data and wrote the paper; Lopes CRP collected data; Alves AMP, Alves EPB and Buttow NC designed the study and edited the manuscript; Linden DR critically analyzed the paper; Zanoni JN analyzed the data.

Supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES, Brasil; NIH grant, No. DK76665

Correspondence to: Nilza Cristina Buttow, PhD, Department of Morphological Sciences, Universidade Estadual de Maringá, Av. Colombo, 5790 Bloco H-79, Maringá, PR. CEP 87020-900, Brazil. ncbuttow@gmail.com

Telephone: +55-44-30114705 Fax: +55-44-30114340

Received: February 15, 2013
Revised: May 20, 2013
Accepted: June 19, 2013
Published online: October 14, 2013
Processing time: 231 Days and 21.8 Hours

Core Tip

Core tip: The present study is the first to report a neuroprotective effect of the flavonoid quercetin in the general population of enteric neurons in the cecum of rats with experimental diabetes mellitus. Quercetin did not reduce the loss of nitrergic neurons in the diabetic rats. This observation suggests that selective changes in the neurochemical code of enteric neurons occur in the presence of quercetin. We propose a causal link between the area and number of glial cells and the size of VIP-IR (reduction in varicosity population) varicosities. Although this link is not fully understood, these observations provide a basis for further studies to clarify the link between glia and VIP-IR varicosities.