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World J Gastroenterol. Oct 7, 2013; 19(37): 6278-6283
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6278
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6278
De novo combined lamivudine and adefovir dipivoxil therapy vs entecavir monotherapy for hepatitis B virus-related decompensated cirrhosis
Jiang-Shan Lian, Lin-Yan Zeng, Jian-Yang Chen, Hong-Yu Jia, Yi-Min Zhang, Dai-Rong Xiang, Liang Yu, Jian-Hua Hu, Ying-Feng Lu, Ling Zheng, Lan-Juan Li, Yi-Da Yang, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China
Author contributions: Lian JS and Zeng LY contributed equally to this work; Lian JS, Zeng LY and Chen JY performed the majority of experiments; Jia HY, Zhang YM, Xiang DR, Yu L, Hu JH, Lu YF provided analytical tools and revised the manuscript; Zheng L, Li LJ and Yang YD designed the study; Lian JS and Yang YD wrote the manuscript.
Supported by the National Key Program for Infectious Diseases of China to Yang YD, 2013ZX10002001; and 12th Five-Year Significant New Drugs Creation Plan of the Ministry of Science and Technology of China to Yang YD, 2011ZX09302-003-03
Correspondence to: Dr. Yi-Da Yang, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. yangyida65@163.com
Telephone: +86-571-87236731 Fax: +86-571-87236755
Received: June 12, 2013
Revised: July 29, 2013
Accepted: August 20, 2013
Published online: October 7, 2013
Processing time: 128 Days and 0.2 Hours
Revised: July 29, 2013
Accepted: August 20, 2013
Published online: October 7, 2013
Processing time: 128 Days and 0.2 Hours
Core Tip
Core tip: This study compared the de novo efficacy of combined lamivudine (LAM) and adefovir dipivoxil (ADV) therapy with that of entecavir (ETV) monotherapy for patients with hepatitis B virus (HBV)-related decompensated liver cirrhosis. Both LAM + ADV combination therapy and ETV monotherapy can effectively inhibit HBV replication, improve liver function, and decrease mortality. The data obtained in this study demonstrate the efficacy and the safety of these treatment regimens for 96 wk in patients with HBV-related decompensated liver cirrhosis.