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World J Gastroenterol. Aug 21, 2013; 19(31): 5144-5149
Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5144
Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5144
HMGB1 gene polymorphisms in patients with chronic hepatitis B virus infection
Chun-Qing Deng, Guo-Hong Deng, Yu-Ming Wang, Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Chun-Qing Deng, Department of Infectious Diseases, the First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Provence, China
Author contributions: Deng CQ and Wang YM designed the research; Deng CQ and Deng GH performed the research and analyzed the data; Deng CQ wrote the paper; Deng GH and Wang YM reviewed and revised the paper; all authors contributed to the study design and interpretation of the data.
Supported by The National Natural Science Foundation of China, grant No. 30972598; The State Key Project Specialized for Infectious Diseases, No. 2012ZX10002-004; and the TMMU Key Project for Clinical Study, No. 2012XLC-005
Correspondence to: Yu-Ming Wang, Professor, Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, No. 35 Gaotanyanzheng Street, Shapingba District, Chongqing 400038, China. wym417@163.com
Telephone: +86-23-68754858 Fax: +86-23-65334998
Received: January 22, 2013
Revised: March 28, 2013
Accepted: July 17, 2013
Published online: August 21, 2013
Processing time: 209 Days and 3.9 Hours
Revised: March 28, 2013
Accepted: July 17, 2013
Published online: August 21, 2013
Processing time: 209 Days and 3.9 Hours
Core Tip
Core tip: We analyzed the relationship between the high mobility group box chromosomal protein 1 (HMGB1) 1176 G/C polymorphism and the susceptibility and outcome to hepatitis B virus (HBV) infection in a large hospital-based case-control study. Our results indicated that patients with 1176G/G genotype of HMGB1 gene are more likely to have a progressive status in HBV infection. Our study emphasizes the importance of HMGB1 in the pathophysiology of HBV-related diseases on the population level and will provide researchers new clue for the further basic research in pathogenesis of chronic HBV infection.