Chen QQ, Yan L, Wang CZ, Wang WH, Shi H, Su BB, Zeng QH, Du HT, Wan J. Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses. World J Gastroenterol 2013; 19(29): 4702-4717 [PMID: 23922467 DOI: 10.3748/wjg.v19.i29.4702]
Corresponding Author of This Article
Jun Wan, MD, Professor, Department of Gastroenterology, Chinese PLA General Hospital, No. 28, Fu Xing Road, Haidian District, Beijing 100853, China. wanjun301@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
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Chen QQ, Yan L, Wang CZ, Wang WH, Shi H, Su BB, Zeng QH, Du HT, Wan J. Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses. World J Gastroenterol 2013; 19(29): 4702-4717 [PMID: 23922467 DOI: 10.3748/wjg.v19.i29.4702]
World J Gastroenterol. Aug 7, 2013; 19(29): 4702-4717 Published online Aug 7, 2013. doi: 10.3748/wjg.v19.i29.4702
Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses
Qian-Qian Chen, Li Yan, Chang-Zheng Wang, Wei-Hua Wang, Hui Shi, Bin-Bin Su, Qing-Huan Zeng, Hai-Tao Du, Jun Wan
Qian-Qian Chen, Li Yan, Chang-Zheng Wang, Wei-Hua Wang, Hui Shi, Bin-Bin Su, Qing-Huan Zeng, Hai-Tao Du, Department of Gastroenterology, Chinese PLA General Hospital, Medical College of PLA, Beijing 100853, China
Jun Wan, Department of Gastroenterology, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Chen QQ and Yan L done this study and wrote the paper; Wang CZ and Wang WH gave experimental instructions; Shi H and Su BB collected data; Zeng QH and Du HT analyzed and interpreted data; Wan J designed this study.
Supported by The National Natural Science Foundation of China, No. 81050027
Correspondence to: Jun Wan, MD, Professor, Department of Gastroenterology, Chinese PLA General Hospital, No. 28, Fu Xing Road, Haidian District, Beijing 100853, China. wanjun301@126.com
Telephone: +86-10-66876266 Fax: +86-404-68295664
Received: February 1, 2013 Revised: June 12, 2013 Accepted: June 19, 2013 Published online: August 7, 2013 Processing time: 185 Days and 10.2 Hours
Core Tip
Core tip: In this study, the following factors were identified: (1) The differentiation of intestinal stem cells in injured gut was determined by detecting Lgr5+ cells; (2) Th1-Th2-Th17-Tregs-related inflammatory and immune cytokine expressions in serum and local intestinal tissues were determined; (3) A Th2 shift and correction of the imbalanced Th17/Tregs were found; (4) Master regulators of Th1, Th2, Th17 and Tregs were detected in bone marrow mesenchymal stem cells -treated trinitrobenzene sulfonic acid-induced colitis; and (5) The passways of Th1-T-bet, Th2-GATA family of transcription factors 3, Th17-retinoid related orphan receptor gamma(t) and Tregs-Foxp3 which serve as important immunoregulators in the correction of immune disorders and enhance the healing of injured intestinal mucosa were identified.
