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World J Gastroenterol. Jul 28, 2013; 19(28): 4590-4595
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4590
Published online Jul 28, 2013. doi: 10.3748/wjg.v19.i28.4590
Increased expression of matrix metalloproteinase-9 associated with gastric ulcer recurrence
Sen-Lin Li, Jing-Run Zhao, Jia-Ping Xie, Qing-Zhu Ma, Qiu-Hua Rong, Department of Gastroenterology, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
Xiao-Yan Ren, Central Laboratory, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
Author contributions: Li SL and Zhao JR contributed equally to this study; Li SL and Zhao JR designed this study; Ren XY, Xie JP, Ma QZ and Rong QH contributed to performance of this study; all the authors contributed to the writing and revision of the manuscript.
Correspondence to: Dr. Jing-Run Zhao, Department of Gastroenterology, Liaocheng People’s Hospital, Dongchang West Road 67, Liaocheng 252000, Shandong Province, China. zhjrun77@163.com
Telephone: +86-635-8272030 Fax: +86-635-8276110
Received: April 2, 2013
Revised: May 20, 2013
Accepted: June 1, 2013
Published online: July 28, 2013
Processing time: 117 Days and 16.3 Hours
Revised: May 20, 2013
Accepted: June 1, 2013
Published online: July 28, 2013
Processing time: 117 Days and 16.3 Hours
Core Tip
Core tip: Gastric ulcer is a multifaceted process including acid secretion, reactive oxygen species generation, prostaglandin inhibition, and extracellular matrix degradation. Gastric mucosal damage is directly associated with extracellular matrix degradation in which matrix metalloproteinases (MMPs) play a crucial role. In this study, the authors compared MMP-9 and tissue inhibitor of metalloproteinase-1 levels in patients with gastric ulcer or chronic superficial gastritis.