Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation

doi:10.3748/wjg.v19.i27.4363

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2013; 19(27): 4363-4373
Published online Jul 21, 2013. doi: 10.3748/wjg.v19.i27.4363

Underexpression of LATS1 TSG in colorectal cancer is associated with promoter hypermethylation

Piotr M Wierzbicki, Krystian Adrych, Dorota Kartanowicz, Marcin Stanislawowski, Anna Kowalczyk, Janusz Godlewski, Iwona Skwierz-Bogdanska, Krzysztof Celinski, Tomasz Gach, Jan Kulig, Bartlomiej Korybalski, Zbigniew Kmiec

Piotr M Wierzbicki, Dorota Kartanowicz, Marcin Stanislawowski, Zbigniew Kmiec, Department of Histology, Faculty of Medicine, Medical University of Gdansk, 80210 Gdansk, Poland

Krystian Adrych, Department of Hepatology and Gastroenterology, Faculty of Medicine, Medical University of Gdansk, 80210 Gdansk, Poland

Anna Kowalczyk, Janusz Godlewski, Department of Human Histology and Embryology, Faculty of Medical Sciences, University of Varmia and Masuria, 10082 Olsztyn, Poland

Iwona Skwierz-Bogdanska, Department of General Surgery, Hospital Ministry Internal Affairs, 80104 Gdansk, Poland

Krzysztof Celinski, Department of Gastroenterology, Medical University of Lublin, 20059 Lublin, Poland

Tomasz Gach, Jan Kulig, 1^st Department of General Surgery, Jagiellonian University, 31008 Cracow, Poland

Bartlomiej Korybalski, Endoscopy Unit, St. Adalbert Hospital, 80462 Gdansk, Poland

Author contributions: Kartanowicz D and Stanislawowski M performed the majority of the molecular experiments; Adrych K, Godlewski J, Skwierz-Bogdanska I, Gach T and Korybalski B collected tissue specimens; Celinski K and Kulig J coordinated and provided tissue collection; Kowalczyk A helped with tissue processing and writing the manuscript; Wierzbicki PM designed the study and molecular assays and wrote the manuscript; Kmiec Z coordinated collaboration among clinics and laboratories and was involved in editing the manuscript.

Supported by Polish Ministry of Science, No. N N402 683940

Correspondence to: Dr. Piotr M Wierzbicki, Department of Histology, Faculty of Medicine, Medical University of Gdansk, 1 Debinki Str., 80210 Gdansk, Poland. pwierzb@gumed.edu.pl

Telephone: +48-58-3491431 Fax: +48-58-3491419

Received: August 3, 2012
Revised: March 4, 2013
Accepted: March 15, 2013
Published online: July 21, 2013
Processing time: 351 Days and 19.9 Hours

Core Tip

Core tip: Searching for new colorectal cancer (CRC) molecular markers is a very important objective, because CRC is one of the most common malignancies in the world and one of the most fatal of human neoplasms. Decreased expression of large tumor suppressor 1 in CRC was associated with promoter hypermethylation, but not microsatellite instability status. Such reduced expression may promote progression of CRC.