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World J Gastroenterol. Jul 14, 2013; 19(26): 4200-4208
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4200
Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4200
Metabonomic studies of pancreatic cancer response to radiotherapy in a mouse xenograft model using magnetic resonance spectroscopy and principal components analysis
Xin-Hong He, Wen-Tao Li, Ya-Jia Gu, Bao-Feng Yang, Wei-Jun Peng, Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Hui-Wen Deng, Yi-Hua Yu, Shanghai Key Laboratory of Functional Magnetic Resonance Imaging, Physics Department, East China Normal University, Shanghai 200062, China
Author contributions: He XH performed the majority of the experiments; Li WT, Gu YJ, Yang BF, Deng HW and Yu YH provided vital reagents and analytical tools, and were also involved in editing the manuscript; Peng WJ designed the study and wrote the manuscript.
Supported by The Medical Imageology Special Purpose Foundation of Cancer Hospital/Cancer Institute Fudan University, No. YX200802
Correspondence to: Wei-Jun Peng, MD, Department of Radiology, Fudan University Shanghai Cancer Center, No. 270, Dong’an Road, Shanghai 200032, China. weijunpeng378@gmail.com
Telephone: +86-21-64175590-3430 Fax: +86-21-64433384
Received: December 25, 2012
Revised: March 22, 2013
Accepted: April 27, 2013
Published online: July 14, 2013
Processing time: 210 Days and 19.7 Hours
Revised: March 22, 2013
Accepted: April 27, 2013
Published online: July 14, 2013
Processing time: 210 Days and 19.7 Hours
Core Tip
Core tip: In the present study, for the first time to our knowledge, high-resolution magic angle spinning proton magnetic resonance spectroscopy and principal components analysis were combined to highlight metabolite profiles of pancreatic cancer after radiotherapy, by analyzing the correlation between radiotherapy effect and metabolic change, and optimizing the therapeutic scheme. The results showed that metabolic profile changes of pancreatic cancer after radiotherapy were closely correlated with therapeutic effect. The outcome of the study is both interesting and beneficial to pathological research, early diagnosis, and therapy evaluation of pancreatic diseases.