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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jun 14, 2013; 19(22): 3423-3432
Published online Jun 14, 2013. doi: 10.3748/wjg.v19.i22.3423
Published online Jun 14, 2013. doi: 10.3748/wjg.v19.i22.3423
Human liver tissue metabolic profiling research on hepatitis B virus-related hepatocellular carcinoma
Shu-Ye Liu, Rikki-Lei Zhang, Hua Kang, Zhi-Juan Fan, Zhi Du, Department of Hepatobiliary Surgery, Tianjin Third Central Hospital, Tianjin 300170, China
Author contributions: Liu SY and Du Z conceived and designed the research, and revised the manuscript; Zhang RL and Kang H performed the experiment, and data acquisition, analysis and interpretation; Fan ZJ collected samples and drafted the manuscript.
Correspondence to: Zhi Du, MD, Department of Hepatobiliary Surgery, Tianjin Third Central Hospital, No. 83 Jintang Road, Hedong District, Tianjin 300170, China. graylion@163.com
Telephone: +86-22-84112299 Fax: +86-22-24384350
Received: December 13, 2012
Revised: March 21, 2013
Accepted: April 3, 2013
Published online: June 14, 2013
Processing time: 172 Days and 12.6 Hours
Revised: March 21, 2013
Accepted: April 3, 2013
Published online: June 14, 2013
Processing time: 172 Days and 12.6 Hours
Core Tip
Core tip: An ultra performance liquid chromatography-mass spectrometry platform was used in the present study to identify characteristic metabolites in hepatitis B virus-related hepatocellular carcinoma tumor tissues. From an orthogonal partial least squares discriminant analysis model established to determine metabolic profiling in the central tumor tissue group, adjacent tissue group and distant tissue group, 49 ions were selected and 14 of these were identified as characteristic metabolites. The detection of these metabolites in tumor tissue not only confirmed the targeted traceability of previously reported serum biomarkers related to cancer diagnosis, but also provided novel targets for anticancer research.