Wang YG, Wang N, Li GM, Fang WL, Wei J, Ma JL, Wang T, Shi M. Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. World J Gastroenterol 2013; 19(21): 3226-3240 [PMID: 23745024 DOI: 10.3748/wjg.v19.i21.3226]
Corresponding Author of This Article
Min Shi, MD, PhD, Department of Gastroenterology, Shanghai Changning Central Hospital, No. 1111 Xianxia Road, Changning district, Shanghai 200336, China. shimingdyx@yeah.net
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Original Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Wang YG, Wang N, Li GM, Fang WL, Wei J, Ma JL, Wang T, Shi M. Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins. World J Gastroenterol 2013; 19(21): 3226-3240 [PMID: 23745024 DOI: 10.3748/wjg.v19.i21.3226]
World J Gastroenterol. Jun 7, 2013; 19(21): 3226-3240 Published online Jun 7, 2013. doi: 10.3748/wjg.v19.i21.3226
Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins
Yu-Gang Wang, Na Wang, Guang-Ming Li, Wen-Li Fang, Jue Wei, Jia-Li Ma, Ting Wang, Min Shi
Yu-Gang Wang, Na Wang, Wen-Li Fang, Jue Wei, Jia-Li Ma, Ting Wang, Min Shi, Department of Gastroenterology, Shanghai Changning Central Hospital, Shanghai 200336, China
Guang-Ming Li, Department of Gastroenterology, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China
Author contributions: Wang YG, Wang N and Shi M designed the study; Wang YG, Wang N, Li GM, Fang WL, Wei J, Wang T and Shi M carried out the study; Wang YG, Wang N, Li GM, Fang WL, Wei J, Wang T and Shi M contributed new reagents and analytic tools; Wang YG, Wei J and Ma JL analyzed the data; Wang YG, Wang N and Shi M wrote the paper.
Supported by Shanghai Municipal Health Bureau Key Disciplines Grant, No. ZK2012A05; National Natural Science Foundation, No. 81070344
Correspondence to: Min Shi, MD, PhD, Department of Gastroenterology, Shanghai Changning Central Hospital, No. 1111 Xianxia Road, Changning district, Shanghai 200336, China. shimingdyx@yeah.net
Telephone: +86-21-62909911 Fax:+86-21-62906478
Received: January 16, 2013 Revised: March 21, 2013 Accepted: April 9, 2013 Published online: June 7, 2013 Processing time: 149 Days and 12.6 Hours
Core Tip
Core tip: Previous research has shown that deacetyltransferase inhibitors not only induce cell cycle arrest, differentiation and apoptosis of many tumor cells in vitro, but also inhibit tumor growth in tumor-bearing animals. They are through the acetylation modification of deacetyltransferase inhibitor on histone. Only a few studies have focused on the acetylation modification by deacetyltransferase on non-histone. This is the first study to identify acetylated proteins in gastric cancer cells before and after exposure to trichostatin A to explore the effect of lysine acetylation of related proteins on the regulation of gastric cancer cell proliferation. Moreover, the lysine-acetylated proteins and the modified sites in AGS cells were assessed. We explored whether ATP5O was obviously acetylated after trichostatin A treatment in AGS cells.
