Brief Article
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. May 28, 2013; 19(20): 3150-3156
Published online May 28, 2013. doi: 10.3748/wjg.v19.i20.3150
Protective effects of two Lactobacillus plantarum strains in hyperlipidemic mice
Li-Xin Wang, Kai Liu, Da-Wei Gao, Ji-Kui Hao
Li-Xin Wang, Kai Liu, Da-Wei Gao, Department of Biological Engineering, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao 066004, Hebei Province, China
Ji-Kui Hao, Department of Chemical and Biological Engineering, Armour College of Engineering, Illinois Institute of Technology, Chicago, IL 60616, United States
Author contributions: Wang LX and Liu K equally contributed to this manuscript; Wang LX performed the majority of experiments; Liu K wrote the manuscript; Gao DW designed the study and was also involved in editing the manuscript; Hao JK revised the English manuscript.
Supported by Chinese Ministry of Education Doctor Degree grant, No. 20101333120011; Hebei Province Natural Science Fund, No. C2011203137 and No. 11965152D; Chinese Postdoctoral grant, No. 480013
Correspondence to: Dr. Da-Wei Gao, Department of Biological Engineering, College of Environmental and Chemical Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, Hebei Province, China. dwgao@ysu.edu.cn
Telephone: +86-335-8387553 Fax: +86-335-8061569
Received: December 7, 2012
Revised: February 3, 2013
Accepted: February 28, 2013
Published online: May 28, 2013
Processing time: 171 Days and 17.4 Hours
Core Tip

Core tip: Protective effects of Lactobacillus plantarum (L. plantarum) CAI6 and L. plantarum SC4 strains on hyperlipidemic mice were found, including regulating lipid metabolism, alleviating hepatic steatosis and reducing cardiovascular disease (CVD) risk. The mechanism of intracorporal antioxidation of Lactobacillus strains may be related to stimulation of nuclear factor-erythroid 2-related factor 2 (Nrf2) expression. Hypolipidemic effect and Nrf2-induced antioxidative defense may contribute to the reduction of CVD risk. We suggest that food fermented by the strains be used as part of the diet to relieve lipid metabolism related metabolic syndrome and to reduce the risk of CVD.