Original Article
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. May 14, 2013; 19(18): 2781-2792
Published online May 14, 2013. doi: 10.3748/wjg.v19.i18.2781
MAWBP and MAWD inhibit proliferation and invasion in gastric cancer
Dong-Mei Li, Jun Zhang, Wen-Mei Li, Jian-Tao Cui, Yuan-Ming Pan, Si-Qi Liu, Rui Xing, You-Yong Lu
Dong-Mei Li, Wen-Mei Li, Jian-Tao Cui, Yuan-Ming Pan, Rui Xing, You-Yong Lu, Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital/Institute, Beijing 100142, China
Dong-Mei Li, Department of Biochemistry and Molecular Biology, School of Medicine, Shihezi University, Shihezi 832000, Xinjiang Uygur Autonomous Region, China
Jun Zhang, Si-Qi Liu, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 101318, China
Author contributions: Li DM performed the majority of experiments and wrote the paper; Zhang J, Xing R and Lu YY designed the research and revised the manuscript; Li WM, Cui JT, Pan YM and Liu SQ provided new reagents and analyzed the data.
Supported by The National Bio-Tech 863 Program, No. 2006AA02A402; and National Natural Science Foundation of China, No. 30901717
Correspondence to: Rui Xing, PhD, Laboratory of Molecular Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital/Institute, No. 52, Fucheng Road, Haidian District, Beijing 100142, China. sherry19820420@hotmail.com
Telephone: +86-10-88196731 Fax: +86-10-88122437
Received: February 5, 2013
Revised: March 27, 2013
Accepted: April 10, 2013
Published online: May 14, 2013
Processing time: 98 Days and 4.6 Hours
Core Tip

Core tip: Our previous study revealed that mitogen-activated protein kinase activator with WD40 repeats (MAWD) and MAWD binding protein (MAWBP), acting as a complex, were differentially expressed in gastric cancer (GC) tissues compared with that in normal gastric tissues. The present study provided direct evidence that MAWBP and MAWD inhibited proliferation and migration of GC cells. Importantly, interaction of MAWBP and MAWD influenced expression of epithelial-mesenchymal transition (EMT) markers induced by transforming growth factor (TGF)-β1 in GC cells. It indicated that coexpression of MAWBP and MAWD inhibited TGF-β1-induced EMT, thus suppressing EMT-aided GC malignant progression.