Original Article
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World J Gastroenterol. May 7, 2013; 19(17): 2621-2628
Published online May 7, 2013. doi: 10.3748/wjg.v19.i17.2621
CYP24A1 inhibition facilitates the anti-tumor effect of vitamin D3 on colorectal cancer cells
János P Kósa, Péter Horváth, János Wölfling, Dóra Kovács, Bernadett Balla, Péter Mátyus, Evelin Horváth, Gábor Speer, István Takács, Zsolt Nagy, Henrik Horváth, Péter Lakatos
János P Kósa, Péter Horváth, Bernadett Balla, Evelin Horváth, Gábor Speer, István Takács, Zsolt Nagy, Henrik Horváth, Péter Lakatos, 1st Department of Internal Medicine, Semmelweis University, H-1083 Budapest, Hungary
János Wölfling, Dóra Kovács, Department of Organic Chemistry, University of Szeged, H-6720 Szeged, Hungary
Péter Mátyus, Department of Organic Chemistry, Semmelweis University, H-1092 Budapest, Hungary
Author contributions: Kósa JP and Lakatos P designed and coordinated the study; Kósa JP, Horváth P, Balla B and Horváth E carried out the cell culture and mRNA experiments; Wölfling J, Kovács D and Mátyus P designed and synthesized the compounds used; Speer G, Takács I, Nagy Z and Horvath H contributed to the data analysis; Kósa JP and Horváth P wrote the paper.
Supported by Research Grants ETT 022/2006 and ETT 151/2009 from the Ministry of Health, Hungary; TÁMOP-4.2.1/B-09/1/KONV-2010-0005 from Creating the Center of Excellence at the University of Szeged, supported by the European Union and co-financed by the European Regional Fund
Correspondence to: János P Kósa, PhD, 1st Department of Internal Medicine, Semmelweis University, Koranyi 2/a, H-1083 Budapest, Hungary. jkosa@bel1.sote.hu
Telephone: +36-1-2100278 Fax: +36-1-2104874
Received: May 23, 2012
Revised: August 21, 2012
Accepted: August 25, 2012
Published online: May 7, 2013
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