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World J Gastroenterol. Sep 28, 2011; 17(36): 4076-4089
Published online Sep 28, 2011. doi: 10.3748/wjg.v17.i36.4076
Published online Sep 28, 2011. doi: 10.3748/wjg.v17.i36.4076
Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis
Malgorzata Zwolinska-Wcislo, Gastroenterology and Hepatology Clinic, Jagiellonian University Medical College, 31-531 Cracow, Poland
Tomasz Brzozowski, Agata Ptak-Belowska, Aneta Targosz, Slawomir Kwiecien, Zbigniew Sliwowski, Department of Physiology, Jagiellonian University Medical College, 31-531 Cracow, Poland
Katarzyna Urbanczyk, Department of Pathomorphology, Jagiellonian University Medical College, 31-531 Cracow, Poland
Author contributions: Zwolinska-Wcislo M designed the study, performed the majority of the experiments and helped with writing of the manuscript; Ptak-Belowska A and Targosz A measured the plasma levels of cytokines, the generation of mucosal prostaglandins and assessed the expression of cytokines in the colonic tissue using molecular techniques; Urbanczyk K performed the histological evaluation of the colonic mucosa; Kwiecien S performed experiments in rats and measured the colonic blood flow; Sliwowski Z evaluated the lesion score, colonic tissue weight and MPO activity; Brzozowski T designed the study, wrote the manuscript and worked on the revised version of this paper.
Supported by The financial grant K/PBW/000067 of the Polish Ministry of Science and Higher Education
Correspondence to: Dr. Tomasz Brzozowski, Professor, Chairman, Department of Physiology, Jagiellonian University Medical College, 16 Grzegorzecka Street, 31-531 Cracow, Poland. mpbrzozo@cyf-kr.edu.pl
Telephone: +48-12-4211006 Fax: +48-12-4222014
Received: February 21, 2011
Revised: June 15, 2011
Accepted: June 22, 2011
Published online: September 28, 2011
Revised: June 15, 2011
Accepted: June 22, 2011
Published online: September 28, 2011
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