Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR

doi:10.3748/wjg.15.3411

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jul 21, 2009; 15(27): 3411-3416
Published online Jul 21, 2009. doi: 10.3748/wjg.15.3411

Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR

Gabriel Hessel, Adriana MA De Tommaso, Gilda Porta, Jose Vassallo, Cecilia AF Escanhoela, Sandra CB Costa, Paula D Andrade, Maria Angela Bellomo-Brandao

Maria Angela Bellomo-Brandao, Department of Pediatrics, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas-SP 13083-970, Brazil

Paula D Andrade, Sandra CB Costa, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas-SP 13083-970, Brazil

Cecilia AF Escanhoela, Jose Vassallo, Department of Pathology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas-SP 13083-970, Brazil

Gilda Porta, Department of Pediatrics, Children’s Institute of Medical School of the University of São Paulo (USP), São Paulo-SP 05403-000, Brazil

Adriana MA De Tommaso, Gabriel Hessel, Department of Pediatrics, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas-SP 13083-970, Brazil

Author contributions: Bellomo-Brandao MA had responsibility for protocol development, laboratory investigation, preliminary data analysis and writing the manuscript; Andrade PD participated in the laboratory investigation; Vassallo J was responsible for immunohistochemistry tests; Porta G, De Tommaso AMA and Costa SCB participated in the development of the protocol; Escanhoela CAF was responsible for histological analysis; Hessel G conceived of the study, and participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.

Correspondence to: Maria Angela Bellomo-Brandao, MD, PhD, Department of Pediatrics, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Aristides Lobo Street, 789. Campinas, São Paulo 13083-060, Brazil. bellomobrandao@globo.com

Telephone: +19-32874560

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Received: September 5, 2008
Revised: June 8, 2009
Accepted: June 15, 2009
Published online: July 21, 2009

Core Tip

Bellomo-Brandao MA, Andrade PD, Costa SC, Escanhoela CA, Vassallo J, Porta G, De Tommaso AM, Hessel G. Cytomegalovirus frequency in neonatal intrahepatic cholestasis determined by serology, histology, immunohistochemistry and PCR. World J Gastroenterol 2009; 15(27): 3411-3416 [PMID: 19610143 DOI: 10.3748/wjg.15.3411]

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