Clinical Trials Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 7, 2024; 30(9): 1108-1120
Published online Mar 7, 2024. doi: 10.3748/wjg.v30.i9.1108
Clinical manifestation, lifestyle, and treatment patterns of chronic erosive gastritis: A multicenter real-world study in China
Ying-Yun Yang, Ke-Min Li, Gui-Fang Xu, Cheng-Dang Wang, Hua Xiong, Xiao-Zhong Wang, Chun-Hui Wang, Bing-Yong Zhang, Hai-Xing Jiang, Jing Sun, Yan Xu, Li-Juan Zhang, Hao-Xuan Zheng, Xiang-Bin Xing, Liang-Jing Wang, Xiu-Li Zuo, Shi-Gang Ding, Rong Lin, Chun-Xiao Chen, Xing-Wei Wang, Jing-Nan Li
Ying-Yun Yang, Ke-Min Li, Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
Gui-Fang Xu, Department of Gastroenterology, Nanjing Drum Tower Hospital, Nanjing 21000, Jiangsu Province, China
Cheng-Dang Wang, Department of Gastroenterology, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China
Hua Xiong, Department of Gastroenterology, Renji Hospital, Shanghai 200127, China
Xiao-Zhong Wang, Department of Gastroenterology, Union Hospital of Fujian Medical University, Fuzhou 350000, Fujian Province, China
Chun-Hui Wang, Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China
Bing-Yong Zhang, Department of Gastroenterology and Hepatology, The People’s Hospital of Zhengzhou University, The Henan Provincial People’s Hospital, Zhengzhou 450003, Henan Province, China
Hai-Xing Jiang, Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Jing Sun, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai Jiao Tong Univesrity, Ruijin Hospital, School Medicine, Shanghai 200025, China
Yan Xu, Department of Gastroenterology and Hepatology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin Province, China
Li-Juan Zhang, Department of Gastroenterology, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China
Hao-Xuan Zheng, Department of Gastroenterology, Nanfang Hospital, Guangzhou 510080, Guangdong Province, China
Xiang-Bin Xing, Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Liang-Jing Wang, Department of Gastroenterology, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Xiu-Li Zuo, Department of Gastroenterology, Shandong University Qilu Hospital, Jinan 250012, Shandong Province, China
Shi-Gang Ding, Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China
Rong Lin, Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Chun-Xiao Chen, Department of Gastroenterology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 315000, Zhejiang Province, China
Xing-Wei Wang, Department of Gastroenterology, Chongqing Daping Hospital, Chongqing 400042, China
Jing-Nan Li, Department of Gastroenterology, Peking Union Medical College Hospital, Beijing 100005, China
Jing-Nan Li, Key Laboratory of Gut Microbiota Translational Medicine Research, Chinese Academy of Medical Science, Beijing 100005, China
Author contributions: Li JN, Yang YY, Xu GF, Wang CD, Wang XZ, Wang CH, Zhang BY, and Jiang HX contributed to the conception and design of the study; Yang YY, Xu GF, Wang CD, Xiong H, Wang XZ, Wang CH, Zhang BY, Jiang HX, Sun J, Xu Y, Yang YY, Xu GF, Wang CD, Xiong H, Wang XZ, Wang CH, Zhang BY, Jiang HX, Sun J, Xu Y, Zhang LJ, Zheng HX, Xing XB, Wang LJ, Zuo XL, Ding SG, Lin R, Chen CX, Wang XW, and Li JN performed the data collection; Yang YY, Li KM, Li JN, Xu Y, Wang LJ, Ding SG, and Lin R performed the data analysis and interpretation; Yang YY, Li KM, and Li JN performed the statistical analysis; Yang YY and Li KM wrote the first draft of the manuscript; Wang CD, Xiong H, Wang XZ, Wang CH, Zhang BY, Jiang HX, Sun J, Xu Y, Wang LJ, Ding SG, and Lin R revised the manuscript; Li JN and Yang YY contributed to funding acquisition; and all authors read and approved the final manuscript.
Supported by the National Key Clinical Specialty Construction Project, No. ZK108000; and CAMS Innovation Fund for Medical Sciences, No. 2021-I2M-C&T-A-001 and No. 2022-I2M-C&T-B-012.
Institutional review board statement: The study is reviewed and approved by the Local Ethics Committees of Peking union medical college hospital (Approval No. S-K700).
Clinical trial registration statement: This study is registered at Chinese Clinical Trial Registry (ChiCTR). The registration identification number is ChiCTR2100047690.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the CONSORT 2010 statement, and the manuscript was prepared and revised according to the CONSORT 2010 statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing-Nan Li, MD, Chief Physician, Department of Gastroenterology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100005, China. pumcjnl@126.com
Received: November 13, 2023
Peer-review started: November 13, 2023
First decision: December 8, 2023
Revised: January 1, 2024
Accepted: February 2, 2024
Article in press: February 2, 2024
Published online: March 7, 2024
Processing time: 114 Days and 0.8 Hours
ARTICLE HIGHLIGHTS
Research background

This multicenter observational study delves into chronic erosive gastritis (CEG) in China, a condition whose clinical characteristics and treatment approaches have been inadequately explored. It illuminates the commonality of CEG and its varied clinical presentations, emphasizing the necessity of a better understanding of its treatment patterns and short-term outcomes.

Research motivation

Addressing the pressing need for clarity in the clinical management of CEG, the study seeks to demystify the disease’s symptomatology, lifestyle influences, endoscopic findings, and treatment efficacies. It aspires to enhance the understanding of CEG’s multifactorial nature and guide more effective, personalized treatment strategies.

Research objectives

To explore the clinical characteristics, treatment patterns, and short-term outcomes in CEG patients in China.

Research methods

Employing a prospective observational cohort approach, the study involved patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosions. It combined questionnaires, endoscopic and pathological evaluations, and follow-up assessments to evaluate treatment responses and lifestyle characteristics, offering a comprehensive view of CEG’s clinical landscape.

Research results

The study reveals the predominance of symptoms like epigastric pain, abdominal distension, and postprandial fullness in CEG, with treatments like mucosal protective agents and proton pump inhibitors showing varying effectiveness. It underscores the non-specific nature of CEG symptoms and the importance of gastroscopy in diagnosis, especially in Asian populations.

Research conclusions

This investigation proposes new insights into CEG, highlighting its multifactorial etiology influenced by lifestyle, obesity, infection, and emotional factors. The study’s findings advocate for individualized treatment strategies based on specific symptom profiles, enhancing treatment efficacy.

Research perspectives

Future research should focus on long-term outcomes of CEG treatments, the sustainability of therapeutic effects, and the identification of potential late-onset side effects. Extending the understanding of CEG’s long-term progression and refining treatment approaches are crucial steps forward.