Wang ZY, Qu YF, Yu TM, Liu ZL, Cheng YG, Zhong MW, Hu SY. Novel subtype of obesity influencing the outcomes of sleeve gastrectomy: Familial aggregation of obesity. World J Gastroenterol 2024; 30(13): 1887-1898 [PMID: 38659480 DOI: 10.3748/wjg.v30.i13.1887]
Corresponding Author of This Article
Ming-Wei Zhong, MD, Professor, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, No. 16766, Jingshi Road, Jinan 250000, Shandong Province, China. zmwgz@126.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Ze-Yu Wang, Yun-Fei Qu, Zeng-Lin Liu, Yu-Gang Cheng, Ming-Wei Zhong, San-Yuan Hu, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan 250000, Shandong Province, China
Ze-Yu Wang, Yun-Fei Qu, Department of Postgraduate, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250000, Shandong Province, China
Tian-Ming Yu, Zeng-Lin Liu, Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine Shandong University, Jinan 250000, Shandong Province, China
Ming-Wei Zhong, State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine, Lunan Pharmaceutical Group Co. Ltd., Linyi 276005, Shandong Province, China
Author contributions: Wang ZY designed and performed the research and wrote the paper; Hu SY and Zhong MW designed the research and supervised the report; Qu YF contributed to the analysis; Yu TM and Liu ZL provided clinical advice; and Cheng YG supervised the report.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital (Approval No. S447).
Informed consent statement: All personal information was encrypted and all data were anonymous. Therefore, informed consent of all study subjects is waived.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ming-Wei Zhong, MD, Professor, Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, No. 16766, Jingshi Road, Jinan 250000, Shandong Province, China. zmwgz@126.com
Received: January 12, 2024 Peer-review started: January 12, 2024 First decision: January 30, 2024 Revised: February 7, 2024 Accepted: March 14, 2024 Article in press: March 14, 2024 Published online: April 7, 2024 Processing time: 82 Days and 3.8 Hours
ARTICLE HIGHLIGHTS
Research background
Sleeve gastrectomy (SG) significantly reduces weight and improves obesity-related comorbidities in patients with obesity. However, differences in surgical outcomes between patients with familial aggregation of obesity (FAO) and those with sporadic obesity (SO) have not been elucidated.
Research motivation
To investigate whether FAO influences the surgical outcomes of SG.
Research objectives
To compare preoperative characteristics, postoperative weight loss, resolution of obesity-related comorbidities, and surgical complications between the FAO and SO groups.
Research methods
In this retrospective study, we recruited 193 patients who underwent SG and categorized them into FAO and SO groups based on the presence of obesity in their first-degree relatives. Propensity score matching analysis was used to match the patients at a 1:1 ratio to eliminate confounding factors.
Research results
The baseline data and incidence of obesity-related comorbidities did not significantly differ between FAO patients and SO patients. Two years postsurgery, the FAO group exhibited a lower total weight loss percentage (P < 0.001) and excess weight loss percentage (P < 0.001) than did the SO group. Significant differences were observed between the two groups in terms of remission rates of type 2 diabetes mellitus (T2DM) (P = 0.031), hyperlipidemia (P = 0.012), nonalcoholic fatty liver disease (P = 0.003), and postoperative reflux occurrence rate (P = 0.038).
Research conclusions
Compared to those in the SO group, the FAO patients in the SO group demonstrated slightly weaker medium-term weight loss outcomes; reduced symptoms of T2DM, hyperlipidemia, and nonalcoholic fatty liver disease; and a decreased postoperative reflux rate.
Research perspectives
This study provides a theoretical basis for the treatment, surgical method selection, and postoperative health management of patients with FAO.
