Zhen BX, Cai Q, Li F. Chemical components and protective effects of Atractylodes japonica Koidz. ex Kitam against acetic acid-induced gastric ulcer in rats. World J Gastroenterol 2023; 29(43): 5848-5864 [PMID: 38074916 DOI: 10.3748/wjg.v29.i43.5848]
Corresponding Author of This Article
Feng Li, PhD, Professor, Department of Medicine, Liaoning University of Traditional Chinese Medicine, No. 77 Shengming 1st Road, Double D Port, Dalian 116600, Liaoning Province, China. zhanglijiayi@163.com
Research Domain of This Article
Chemistry, Medicinal
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 21, 2023; 29(43): 5848-5864 Published online Nov 21, 2023. doi: 10.3748/wjg.v29.i43.5848
Chemical components and protective effects of Atractylodes japonica Koidz. ex Kitam against acetic acid-induced gastric ulcer in rats
Bi-Xian Zhen, Qian Cai, Feng Li
Bi-Xian Zhen, Qian Cai, Feng Li, Department of Medicine, Liaoning University of Traditional Chinese Medicine, Dalian 116600, Liaoning Province, China
Author contributions: Li F and Cai Q designed the experiment; Zhen BX completed the whole experiment and wrote the manuscript; and all authors approved the final version of the article.
Supported byNational Natural Science Foundation of China, No. 81973478; Liaoning Revitalization Talents Program, China, No. XLYC2002004; and Natural Science Foundation of Liaoning Province, China, No. 2019-ZD-0443.
Institutional animal care and use committee statement: The Laboratory Animal Center and Animal Care & Welfare Committee of Liaoning University of TCM approved the animal experiments.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Li, PhD, Professor, Department of Medicine, Liaoning University of Traditional Chinese Medicine, No. 77 Shengming 1st Road, Double D Port, Dalian 116600, Liaoning Province, China. zhanglijiayi@163.com
Received: August 30, 2023 Peer-review started: August 30, 2023 First decision: October 8, 2023 Revised: October 21, 2023 Accepted: November 7, 2023 Article in press: November 7, 2023 Published online: November 21, 2023 Processing time: 81 Days and 14.4 Hours
ARTICLE HIGHLIGHTS
Research background
Gastric ulcer (GU) is a common digestive system disease. In addition to western medicine treatment, more and more Chinese herbs have become the first choice for alternative treatment due to their long history of use, high efficacy, low side effects and low price.
Research motivation
Although the herbal medicine Atractylodes japonica Koidz. ex Kitam. (A. japonica) has an obvious therapeutic effect on GU, there are few relevant mechanism studies at present.
Research objectives
The object of this study is to investigate the protective effects of A. japonica on acetic acid-induced GU rats.
Research methods
We used ultra performance liquid chromatography tandem mass spectrometry, hematoxylin-eosin stain, enzyme-linked immunosorbent assay, real-time reverse transcription polymerase chain reaction and acetic acid-induced GU model to evaluate the therapeutic effect of A. japonica.
Research results
48 chemical constituents of A. japonica were identified, the herb significantly improved the pathological damage of gastric tissues, increased the expression levels of anti-inflammatory factors, decreased the expression levels of proinflammatory factors, restored the levels of factors about ulcer healing and energy metabolism. and identified 10 potential differential metabolites and enriched 7 related metabolic pathways of metabolomic analysis.
Research conclusions
The therapeutic effect of A. japonica on GU rats is closely related to anti-inflammation and repair of gastric injury, and is regulated and treated through a combination of multiple pathways.
Research perspectives
These findings contribute to the understanding of the potential mechanism of A. japonica to improve acetic acid-induced GU, and will provide great importance for the development and clinical application of A. japonica.
