Li SY, Yang MQ, Liu YM, Sun MJ, Zhang HJ. Endoscopic and pathological characteristics of de novo colorectal cancer: Retrospective cohort study. World J Gastroenterol 2023; 29(18): 2836-2849 [PMID: 37274065 DOI: 10.3748/wjg.v29.i18.2836]
Corresponding Author of This Article
Hui-Jing Zhang, MD, Professor, Department of Endoscopy, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. hjzhang@cmu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
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Li SY, Yang MQ, Liu YM, Sun MJ, Zhang HJ. Endoscopic and pathological characteristics of de novo colorectal cancer: Retrospective cohort study. World J Gastroenterol 2023; 29(18): 2836-2849 [PMID: 37274065 DOI: 10.3748/wjg.v29.i18.2836]
Shi-Yang Li, Mei-Qi Yang, Yi-Ming Liu, Ming-Jun Sun, Hui-Jing Zhang, Department of Endoscopy, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Zhang HJ had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis; Zhang HJ, Li SY, and Yang MQ were responsible for protocol/project development; Li SY, Yang MQ, and Zhang HJ performed data analysis; Li SY, Yang MQ, Liu YM, and Sun MJ performed data collection or management; Yang MQ and Zhang HJ were responsible for manuscript writing/editing; Li SY and Yang MQ, these two authors, contributed equally to this work.
Supported byNatural Science Foundation of Liaoning Province, China, No. 2022-YGJC-71.
Institutional review board statement: The study was reviewed and approved by the Research Ethics Committee of the First Affiliated Hospital of China Medical University Institutional Review Board, No. [2021]2021-68-2.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Participants gave informed consent for data sharing.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Corresponding author: Hui-Jing Zhang, MD, Professor, Department of Endoscopy, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. hjzhang@cmu.edu.cn
Received: March 28, 2023 Peer-review started: March 28, 2023 First decision: April 10, 2023 Revised: April 14, 2023 Accepted: April 19, 2023 Article in press: April 19, 2023 Published online: May 14, 2023 Processing time: 43 Days and 22.6 Hours
ARTICLE HIGHLIGHTS
Research background
The small colorectal small tumors usually be ignored during colonoscopy. However, many depressed or flat lesions have substantial invasion and metastasis. De novo colorectal cancer (CRC) is one type of small tumor related to poor prognosis. And some endoscopists could not distinguish de novo CRC during the examination.
Research motivation
Some small lesions were cut off directly in the examination without computed tomography imaging and endoscopic ultrasound. This may lead to mistreatment because endoscopists often ignore the judgment of invasion depth. The de novo CRC may have a deep invasion layer.
Research objectives
This study aimed to comprehensively review de novo CRCs and provide a reference atlas for future studies and analyze the features of de novo CRCs to distinguish them from non-neoplastic polyps.
Research methods
This study collected clinical and pathological information on de novo patients and stained E-cadherin and vimentin by immunohistochemistry. Based on this information, we analyzed the characteristic of de novo CRC and the relative correlation between different indicators.
Research results
This study highlights that de novo CRCs have special endoscopic and pathological features that distinguish them from traditional adenocarcinomas. It is also the first study paying attention to chicken skin mucosa invasive depth measurement. More importantly, this study summarized several factors relevant to invasion depth and provide tremendous help in clinical practice to increase diagnostic ability.
Research conclusions
This first study pointed out the relationship between de novo CRC and epithelial-mesenchymal transition related genes. And it is the first study put forward that chicken skin mucosa indicates the depth of invasion.
Research perspectives
We will further study the molecular biological difference between de novo CRC and carcinoma in adenoma CRC to discover the mechanism of invasion and metastasis of de novo CRCs.
