Saito M, Yamamura T, Nakamura M, Maeda K, Sawada T, Ishikawa E, Mizutani Y, Ishikawa T, Kakushima N, Furukawa K, Ohno E, Kawashima H, Ishigami M, Fujishiro M. Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching. World J Gastroenterol 2021; 27(47): 8182-8193 [PMID: 35068862 DOI: 10.3748/wjg.v27.i47.8182]
Corresponding Author of This Article
Takeshi Yamamura, MD, PhD, Assistant Professor, Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 4668550, Japan. tyamamu@med.nagoya-u.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Masashi Saito, Takeshi Yamamura, Masanao Nakamura, Eri Ishikawa, Yasuyuki Mizutani, Takuya Ishikawa, Naomi Kakushima, Kazuhiro Furukawa, Eizaburo Ohno, Masatoshi Ishigami, Mitsuhiro Fujishiro, Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya 4668550, Japan
Keiko Maeda, Tsunaki Sawada, Hiroki Kawashima, Department of Endoscopy, Nagoya University Hospital, Nagoya 4668550, Japan
Author contributions: Saito M and Yamamura T were the guarantors and designed the study; Saito M, Yamamura T, Nakamura M, Kawashima H, and Ishikawa T participated in the acquisition, analysis, and interpretation of the data; Saito M drafted the initial manuscript; Ohno E, Yamamura T, Maeda K, Sawada T, Ishikawa E, Mizutani Y, Kakushima N, and Furukawa K revised the article critically for important intellectual content; Yamamura T and Nakamura M contributed to statistical analysis; Fujishiro M made final approval of the article; all authors have read and approved the final manuscript.
Institutional review board statement: This real-world retrospective study was approved by the Ethical Review Board of the Nagoya University Hospital (2015-0449).
Informed consent statement: Informed consent was obtained in the form of opt-out on the website.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Takeshi Yamamura, MD, PhD, Assistant Professor, Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 4668550, Japan. tyamamu@med.nagoya-u.ac.jp
Received: June 17, 2021 Peer-review started: June 17, 2021 First decision: July 2, 2021 Revised: July 15, 2021 Accepted: December 7, 2021 Article in press: December 7, 2021 Published online: December 21, 2021 Processing time: 182 Days and 18 Hours
ARTICLE HIGHLIGHTS
Research background
Cold polypectomy (CP) is widely used as a simple and safe procedure for small colorectal polyps. However, there is concern that recurrence rate following CP may be higher than Hot polypectomy (HP) because of unidentified margins of excised specimens and the lack of tumor suppression effect by coagulation.
Research motivation
There were few reports that observed the course over long periods of time after CP in clinical practice. It is important to compare and evaluate the recurrence rate following CP and HP.
Research objectives
The aim of this study was to evaluate the presence of local recurrence following CP and HP using propensity score matching.
Research methods
We analyzed 275 patients who underwent polypectomy for non-pedunculated colorectal polyps less than 10 mm (959 Lesions) and follow-up endoscopy subsequently. We divided them into the CP group (706 Lesions) and the HP group (253 Lesions). Using propensity score matching, we extracted 215 Lesions in each group and evaluated the local recurrence of CP in the real clinic using medical records.
Research results
The local recurrence rate was 0.93% in the CP group and 0.93% in the HP group, without a significant difference (P = 0.688).
Research conclusions
Local recurrence after CP was equivalent to that following HP in clinical practice. CP is useful and safe in the treatment of non-pedunculated polyps of less than 10 mm.
Research perspectives
Future prospective studies with a larger number of patients and longer follow-up periods are needed in clinical practice.
