Wang H, Esemu-Ezewu P, Pan J, Ivanovska J, Gauda EB, Belik J. Adiponectin and the regulation of gastric content volume in the newborn rat. World J Gastroenterol 2021; 27(33): 5566-5574 [PMID: PMC8433619 DOI: 10.3748/wjg.v27.i33.5566]
Corresponding Author of This Article
Jaques Belik, FRCP (C), MD, Professor, Department of Paediatrics and Physiology, The Hospital for Sick Children, 555 University Ave, Toronto M5G 1X8, Ontario, Canada. jaques.belik@sickkids.ca
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 7, 2021; 27(33): 5566-5574 Published online Sep 7, 2021. doi: 10.3748/wjg.v27.i33.5566
Adiponectin and the regulation of gastric content volume in the newborn rat
Huanhuan Wang, Paul Esemu-Ezewu, Jingyi Pan, Julijana Ivanovska, Estelle B Gauda, Jaques Belik
Huanhuan Wang, Paul Esemu-Ezewu, Jingyi Pan, Julijana Ivanovska, Estelle B Gauda, Department of Paediatrics, The Hospital for Sick Children, Toronto M5G 1X8, Ontario, Canada
Jaques Belik, Department of Paediatrics and Physiology, The Hospital for Sick Children, Toronto M5G 1X8, Ontario, Canada
Author contributions: Wang H, Esemu-Ezewu P, Pan J and Ivanovska J performed the experiments, acquired and analyzed the data and contributed to drafting the manuscript; Gauda EB and Belik J designed, coordinated the study and finalized the manuscript.
Supported byCanadian Institutes of Health Research, No. CIA310955.
Institutional animal care and use committee statement: All procedures were conducted in accordance with the Canadian Animals for Research Act and Canadian Council on Animal Care regulations, and the Hospital for Sick Children Research Institute Animal Care Committee approved the study, No. 1000046424.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at jaques.belik@sickkids.ca.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jaques Belik, FRCP (C), MD, Professor, Department of Paediatrics and Physiology, The Hospital for Sick Children, 555 University Ave, Toronto M5G 1X8, Ontario, Canada. jaques.belik@sickkids.ca
Received: March 9, 2021 Peer-review started: March 9, 2021 First decision: May 1, 2021 Revised: May 12, 2021 Accepted: August 12, 2021 Article in press: August 12, 2021 Published online: September 7, 2021 Processing time: 178 Days and 10.8 Hours
ARTICLE HIGHLIGHTS
Research background
Oral intake depends on the gastric ability to accommodate the food bolus. The preterm infant has a lower gastric capacity, normalized to body weight, when compared with adults, thus potentially limiting their milk intake. Yet, we previously shown that one-week rat pups milk intake is greater than observed, as they mature.
Research motivation
The main rationale for the study experiments was to understand the mechanism accounting for greater food accommodation early in life.
Research objectives
The main objective was to evaluate the hypothesis that the adiponectin in breast milk increases the newborn rat ability to accommodate the food bolus by reducing the fundic muscle tone.
Research methods
Rat freshly dispersed smooth muscle cells were used to measure the adiponectin effect on carbachol-induced fundic muscle shortening.
Research results
Adiponectin significantly reduced the carbachol-stimulated smooth muscle cells shortening independently of age, via large-conductance Ca2+ sensitive K+ channel activation.
Research conclusions
Breast milk containing adiponectin regulates the newborn rat milk intake by increasing the gastric fundic accommodation potential.
Research perspectives
Maternal-neonatal interaction via breast milk components content provides a novel and likely important regulatory role on intake volume early in life.
