Yu TN, Mao YY, Wei FQ, Liu H. Cystic duct cancer: Should it be deemed as a type of gallbladder cancer? World J Gastroenterol 2019; 25(44): 6541-6550 [PMID: 31802833 DOI: 10.3748/wjg.v25.i44.6541]
Corresponding Author of This Article
Hui Liu, PhD, Research Assistant Professor, Zhejiang Provincial Key Laboratory of Laparoscopic Technology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China. lhui2010@zju.edu.cn
Research Domain of This Article
Medicine, Research & Experimental
Article-Type of This Article
Retrospective Study
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Yu TN, Mao YY, Wei FQ, Liu H. Cystic duct cancer: Should it be deemed as a type of gallbladder cancer? World J Gastroenterol 2019; 25(44): 6541-6550 [PMID: 31802833 DOI: 10.3748/wjg.v25.i44.6541]
World J Gastroenterol. Nov 28, 2019; 25(44): 6541-6550 Published online Nov 28, 2019. doi: 10.3748/wjg.v25.i44.6541
Cystic duct cancer: Should it be deemed as a type of gallbladder cancer?
Tu-Nan Yu, Ying-Ying Mao, Fang-Qiang Wei, Hui Liu
Tu-Nan Yu, Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Ying-Ying Mao, Department of Epidemiology and Biostatistics, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang Province, China
Fang-Qiang Wei, Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang Province, China
Hui Liu, Zhejiang Provincial Key Laboratory of Laparoscopic Technology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China
Author contributions: Mao YY, Wei FQ and Liu H designed the research; Yu TN, Mao YY, Wei FQ and Liu H performed the research; Yu TN and Liu H analyzed the data; Yu TN, Mao YY, Wei FQ and Liu H wrote the paper.
Supported byZhejiang Provincial Natural Science Foundation of China, No. LQ17H030003.
Institutional review board statement: The data in this study was obtained from the SEER database and the National Cancer Institute had given us permission to access data for researching (Reference number: 10536-Nov2017). Given that SEER data is de-identified and ethics approval is waived, this study was exempted from Institutional Research Board review.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that are publicly available from the SEER database.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
Corresponding author: Hui Liu, PhD, Research Assistant Professor, Zhejiang Provincial Key Laboratory of Laparoscopic Technology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang Province, China. lhui2010@zju.edu.cn
Telephone: +86-571-86006653 Fax: +86-571-86006653
Received: August 16, 2019 Peer-review started: August 16, 2019 First decision: October 14, 2019 Revised: October 24, 2019 Accepted: November 13, 2019 Article in press: November 13, 2019 Published online: November 28, 2019 Processing time: 104 Days and 8.1 Hours
ARTICLE HIGHLIGHTS
Research background
According to the current guidelines, cystic duct cancer (CC) is categorized as a type of gallbladder cancer (GC), which has the worst prognosis among all types of biliary cancers.
Research motivation
In previous studies, no direct epidemiological evidence verified that CC was more similar to GC, rather than extrahepatic cholangiocarcinoma (EC).
Research objectives
This study aimed to investigate the categorization of CC based on population-level data.
Research methods
We used three taxonomic methods for analysis, including Fisher’s discriminant, binary logistics and artificial neuron network models.
Research results
The T staging system of perihilar cholangiocarcinoma (a type of EC) better discriminated CC prognosis than that of GC. By using the three taxonomic models, the majority (75.0%-77.8%) of CC cases were categorized as EC.
Research conclusions
Our study suggested that CC should be categorized as a type of EC, not GC.
Research perspectives
Aggressive surgical attitude might be considered in CC cases, to see whether long-term prognosis could be immensely improved like the situation in EC. Future studies with larger sample size are needed.
