Published online Oct 21, 2019. doi: 10.3748/wjg.v25.i39.6016
Peer-review started: August 24, 2019
First decision: September 10, 2019
Revised: September 17, 2019
Accepted: September 27, 2019
Article in press: September 27, 2019
Published online: October 21, 2019
Processing time: 58 Days and 9.1 Hours
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has been adopted by liver surgeons. However, ALPPS with a partial split has been proposed recent years. Conflicting results have been reported between the ALPPS and partial split of the liver parenchyma in ALPPS (p-ALPPS). This systematic review and meta-analysis evaluated the difference in the future liver remnant (FLR) hypertrophy rate, postoperative morbidity and mortality rates between the ALPPS and p-ALPPS.
The FLR hypertrophy rate and safety between ALPPS and p-ALPPS are controversial.
To compare the currently reported results between ALPPS and p-ALPPS to confirm which is better for patients.
We systematically reviewed literatures on the ALPPS and p-ALPPS, and included relevant studies for meta-analysis.
The total effects indicated no difference in the FLR hypertrophy rate or perioperative morbidity and mortality rates between the ALPPS and p-ALPPS groups. However, p-ALPPS is safer than ALPPS in patients without cirrhosis and exhibits the same rate of FLR hypertrophy.
In non-cirrhotic patients, p-ALPPS resulted in the same FLR hypertrophy rate compared with the ALPPS, and is safer than ALPPS.
More studies to compare ALPPS with p-ALPPS in cirrhosis patients should be carried out.