Xiong Y, Chen QQ, Chai NL, Jiao SC, Ling Hu EQ. Endoscopic trans-esophageal submucosal tunneling surgery: A new therapeutic approach for diseases located around the aorta ventralis. World J Gastroenterol 2019; 25(1): 85-94 [PMID: 30643360 DOI: 10.3748/wjg.v25.i1.85]
Corresponding Author of This Article
En-Qiang Ling Hu, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China. linghuenqiang@sina.vip.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Basic Study
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jan 7, 2019 (publication date) through Mar 1, 2026
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Journal Information of This Article
Publication Name
World Journal of Gastroenterology
ISSN
1007-9327
Publisher of This Article
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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Xiong Y, Chen QQ, Chai NL, Jiao SC, Ling Hu EQ. Endoscopic trans-esophageal submucosal tunneling surgery: A new therapeutic approach for diseases located around the aorta ventralis. World J Gastroenterol 2019; 25(1): 85-94 [PMID: 30643360 DOI: 10.3748/wjg.v25.i1.85]
Ying Xiong, Qian-Qian Chen, Ning-Li Chai, En-Qiang Ling Hu, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China
Ying Xiong, Department of Gastroenterology and Hepatology, No. 1 Central Hospital of Baoding, Baoding 071000, Hebei Province, China
Shun-Chang Jiao, Department of Oncology, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Xiong Y and Chen QQ are both the first authors and contributed equally to this work. Ling Hu EQ and Jiao SC designed the research and are both corresponding authors ; Xiong Y performed the research; Chai NL contributed new reagents or analytic tools; Chen QQ analyzed the data; Chen QQ and Xiong Y wrote the paper.
Supported byScientific Research Support Fund for Chinese PLA General Hospital, No. 2012FC-TSYS-3035.
Institutional animal care and use committee statement: This study was approved by the Institutional Animal Care and Use Committee of the Chinese PLA General Hospital, Beijng, China. Appropriate measures were taken to minimize pain or discomfort of the animals.
Conflict-of-interest statement: The authors declare that there is no conflict of interest regarding the publication of this article.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at enqianglinghu2017@163.com and jiaoshunchang001@163.com.
ARRIVE guidelines statement: The ARRIVE guidelines have been adopted.
Corresponding author: En-Qiang Ling Hu, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China. linghuenqiang@sina.vip.com
Telephone: +86-10-55499405 Fax: +86-404-55499305
Received: May 27, 2018 Peer-review started: May 27, 2018 First decision: July 4, 2018 Revised: August 22, 2018 Accepted: October 5, 2018 Article in press: October 5, 2018 Published online: January 7, 2019 Processing time: 225 Days and 22.3 Hours
ARTICLE HIGHLIGHTS
Research background
Surgical procedures are shifting paradigms in minimally invasive surgery nowadays, including natural orifice transluminal endoscopic surgery (NOTES), which is a technology of utilizing a flexible endoscope through a natural orifice to diagnose diseases and perform surgeries. The emergence of endoscopic tunnel technique makes the diseases which used to need surgical or laparoscopic surgical treatments enter into the endoscopic therapy.
Research motivation
We attempted to put forward a new approach using endoscopic tunneling techniques to perform NOTES, which was named endoscopic trans-esophageal submucosal tunneling surgery (EESTS).
Research objectives
To assess the efficiency of endoscopic trans-esophageal submucosal tunneling surgery technique for diseases located around the aorta ventralis.
Research methods
We simulated surgeries in a porcine model and to assess the efficiency of this new strategy.
Research results
One pig died from intraperitoneal hemorrhage after doing partial splenectomy, while the other pigs were alive after successfully operating all surgeries.
Research conclusions
We confirmed that EESTS is feasible and safe.
Research perspectives
EESTS by the submucosal tunneling technique to simulate surgeries for diseases located around the aorta ventralis is feasible, efficient, and relatively safe in a porcine model at least. Developing new endoscopic instruments suitable for the technique will be one of the future directions. However, the safety of profile has to be improved before adopting in a clinical setting.
