Liu Y, Wang YJ, Wang SY, Xie CY, Zhou M, Zhao EH, Shen XY, Pan JY, Xu B, Xu TC. Metabolic memory in the gut: The microbiota-epigenetic crosstalk orchestrating obesity onset and novel therapeutic landscapes. World J Gastroenterol 2026; 32(27): 120135 [DOI: 10.3748/wjg.120135]
Andrzej S Tarnawski, MD, PhD, Professor
July 20, 2026, 00:28
This review provides a comprehensive, mechanistically insightful synthesis of the emerging interplay among the gut microbiota, epigenetic regulation, and metabolic memory in obesity. Although the overall concept is not entirely novel, the integration of recent evidence and discussion of potential therapeutic strategies make this a timely and valuable contribution to the field.
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Tian-Cheng Xu
July 20, 2026, 02:11
Dear Professor Andrzej S Tarnawski
Thank you so much for your thoughtful and encouraging positive comments on our review manuscript. We are truly delighted that you recognize our comprehensive summary and mechanistic analysis exploring the crosstalk between gut microbiota, epigenetic regulation and metabolic memory in obesity. It means a great deal to us that you consider our integrated collation of cutting-edge research data and discussion of therapeutic interventions to be a timely and valuable addition to this research field. Your high recognition will greatly motivate us to further polish this idea for future publication.
Best regards,
Tiancheng Xu
Nanjing University of Chinese Medicine
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