Liu Y, Wang HX, Lu N, Mao YS, Liu F, Wang Y, Zhang HR, Wang K, Wu M, Zhao XH. Translocation of annexin I from cellular membrane to the nuclear membrane in human esophageal squamous cell carcinoma. World J Gastroenterol 2003; 9(4): 645-649 [PMID: 12679902 DOI: 10.3748/wjg.v9.i4.645]
Corresponding Author of This Article
Dr. Xiao-Hang Zhao, National Lab. of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing P. O. Box 2258, Beijing 100021, China. zhaoxh@pubem.cicams.ac.cn
Article-Type of This Article
Esophageal Cancer
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World J Gastroenterol. Apr 15, 2003; 9(4): 645-649 Published online Apr 15, 2003. doi: 10.3748/wjg.v9.i4.645
Translocation of annexin I from cellular membrane to the nuclear membrane in human esophageal squamous cell carcinoma
Yu Liu, Hui-Xin Wang, Ning Lu, You-Sheng Mao, Fang Liu, Ying Wang, Hai-Rong Zhang, Kun Wang, Min Wu, Xiao-Hang Zhao
Yu Liu, Hui-Xin Wang, Fang Liu, Ying Wang, Min Wu, Xiao-Hang Zhao, National Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China
Ning Lu, Department of Pathology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China
You-Sheng Mao, Department of Pectoral Surgery, Cancer Institute and Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China
Hai-Rong Zhang, Kun Wang, Beijing Yanjing Hospital, Beijing 100037, China
Author contributions: All authors contributed equally to the work.
Supported by the Major State Basic Research Development Program of China, No.G1998051205; the National Hi-Tech R & D Program of China, No.2001AA227091; the National Natural Science Foundation of China, No. 39990570 (Major Program) and No. 30171049 (General Program), and the National Science Fund for Distinguished Young Scholars (No.30225045)
Correspondence to: Dr. Xiao-Hang Zhao, National Lab. of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing P. O. Box 2258, Beijing 100021, China. zhaoxh@pubem.cicams.ac.cn
Telephone: +86-10-67709015 Fax: +86-10-67709015
Received: December 25, 2002 Revised: December 29, 2002 Accepted: January 5, 2003 Published online: April 15, 2003
Abstract
AIM: To investigate the alteration of the annexin I subcellular localization in esophageal squamous cell carcinoma (ESCC) and the correlation between the translocation and the tumorigenesis of ESCC.
METHODS: The protein localization of annexin I was detected in both human ESCC tissues and cell line via the indirect immunofluorescence strategy.
RESULTS: In the normal esophageal epithelia the annexin I was mainly located on the plasma membrane and formed a consecutive typical trammels net. Annexin I protein also expressed dispersively in cytoplasm and the nuclei without specific localization on the nuclear membrane. In esophageal cancer annexin I decreased very sharply with scattered disappearance on the cellular membrane, however it translocated and highly expressed on the nuclear membrane, which was never found in normal esophageal epithelia. In cultured esophageal cancer cell line annexin I protein was also focused on the nuclear membrane, which was consistent with the result from esophageal cancer tissues.
CONCLUSION: This observation suggests that the translocation of annexin I protein in ESCC may correlate with the tumorigenesis of the esophageal cancer.
