Esophageal Cancer
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 15, 2003; 9(3): 412-416
Published online Mar 15, 2003. doi: 10.3748/wjg.v9.i3.412
HLA-DRB1 allele polymorphisms in genetic susceptibility to esophageal carcinoma
Jun Lin, Chang-Sheng Deng, Jie Sun, Xian-Gong Zheng, Xing Huang, Yan Zhou, Ping Xiong, Ya-Ping Wang
Jun Lin, Chang-Sheng Deng, Jie Sun, Xian-Gong Zheng, Xing Huang, Yan Zhou, Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China
Ping Xiong, Department of Immunology, Tongji Medical Collge of Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Ya-Ping Wang, State Key Lab, Institute of Hydrobiology, The Chinese Academy of Sciences, Wuhan 430077, Hubei Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr Jun Lin, Department of Gastroenterology, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China. linjun64@yahoo.com.cn
Telephone: +86-27-87335914 Fax: +86-27-87307622
Received: July 19, 2001
Revised: August 13, 2001
Accepted: August 27, 2001
Published online: March 15, 2003
Abstract

AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal carcinoma in Han Chinese in Hubei Province.

METHODS: HLA-DRB1 allele polymorphisms were typed by polymerase chain reaction with sequence-specific primers (PCR-SSP) in 42 unrelated patients with esophageal cancer and 136 unrelated normal control subjects and the associated HLA-DRB1 allele was measured by nucleotide sequence analysis with PCR.SAS software was used in statistics.

RESULTS: Allele frequency (AF) of HLA-DRB1*0901 was significantly higher in esophageal carcinoma patients than that in the normal controls (0.2500 vs 0.1397, P = 0.028, the odds ratio 2.053, etiologic fraction 0.1282). After analyzed the allele nucleotide sequence of HLA-DRB1*0901 which approachs to the corresponded exon 2 sequence of the allele in genebank. There was no association between patients and controls in the rested HLA-DRB1 alleles.

CONCLUSION: HLA-DRB1*0901 allele is more common in the patients with esophageal carcinoma than in the healthy controls, which is positively associated with the patients of Hubei Han Chinese. Individuals carrying HLA-DRB1*0901 may be susceptible to esophageal carcinoma.

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