Brief Reports
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 15, 2003; 9(12): 2863-2865
Published online Dec 15, 2003. doi: 10.3748/wjg.v9.i12.2863
Expression of PCNA and CD44mRNA in colorectal cancer with venous invasion and its relationship to liver metastasis
Shu-Qiang Yue, Yan-Ling Yang, Ke-Feng Dou, Kai-Zong Li
Shu-Qiang Yue, Yan-Ling Yang, Ke-Feng Dou, Kai-Zong Li, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Author contributions: All authors contributed equally to the work.
Correspondence to: Kai-Zong Li, Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, 710032 Xi’an, Shaanxi Province, China. gdwk@fmmu.edu.cn
Telephone: +86-29-3375259 Fax: +86-29-3375561
Received: May 13, 2003
Revised: May 26, 2003
Accepted: June 2, 2003
Published online: December 15, 2003
Abstract

AIM: To investigate the expression of proliferating cell nuclear antigen (PCNA) and CD44mRNA in colorectal cancer with venous invasion and its relationship with liver metastasis.

METHODS: Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the expression of PCNA and CD44mRNA in 31 cases of colorectal cancer with venous invasion.

RESULTS: Positive expression rates of PCNA and CD44mRNA in colorectal cancer were higher than those without liver metastasis (P < 0.05 and P < 0.01). In case of colorectal cancer with liver metastasis, strongly positive rates of PCNA and CD44mRNA were 94.1% and 70.6%, respectively, significantly higher than those without liver metastasis. There was a positive relationship between the expressions of PCNA and CD44mRNA (r = 0.67, P < 0.05).

CONCLUSION: Detection of PCNA and CD44mRNA expression in colorectal cancer may be useful for evaluating liver metastasis of cancer cells.

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