Prevention and therapy of fungal infection in severe acute pancreatitis: A prospective clinical study

doi:10.3748/wjg.v9.i11.2619

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Nov 15, 2003 (publication date) through Sep 16, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 15, 2003; 9(11): 2619-2621
Published online Nov 15, 2003. doi: 10.3748/wjg.v9.i11.2619

Prevention and therapy of fungal infection in severe acute pancreatitis: A prospective clinical study

Yue-Ming He, Xin-Sheng Lv, Zhong-Li Ai, Zhi-Su Liu, Qun Qian, Quan Sun, Ji-Wei Chen, Dao-Xiong Lei, Cong-Qing Jiang, Yu-Fong Yuan

Yue-Ming He, Xin-Sheng Lv, Department of General Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China

Zhong-Li Ai, Zhi-Su Liu, Qun Qian, Quan Sun, Ji-Wei Chen, Dao-Xiong Lei, Cong-Qing Jiang, Yu-Fong Yuan, Department of General Surgery, Zhongnan Hospital, Wuhan University, Wuhan 430071, Hubei Province, China

Author contributions: All authors contributed equally to the work.

Correspondence to: Dr. Yue-Ming He, Department of General Surgery, Zhongnan Hospital, Wuhan University, 169 Donghu Road, Wuhan 430071, Hubei Province, China. heym@medmail.com.cn

Telephone: +86-27-67813297 Fax: +86-27-87330795

Received: May 10, 2003
Revised: May 20, 2003
Accepted: June 2, 2003
Published online: November 15, 2003

Abstract

AIM: To investigate the prevention and therapy of fungal infection in patients with severe acute pancreatitis (SAP).

METHODS: Seventy patients with SAP admitted from Jan. 1998 to Dec. 2002 were randomly divided into garlicin prevention group, fluconazole (low dosage) prevention group and control group. The incidence of fungal infection, the fungal clearance and mortality after treatment were compared.

RESULTS: The incidence of fungal infection in garlicin group and fluconazole group was lower than that in control group (16% vs 30%, P < 0.05 and 9% vs 30%, P < 0.01, respectively). Amphotericin B or therapy-dose fluconazole had effects on patients with fungal infection in garlicin group and control group, but had no effects on patients with fungal infection in fluconzole group.

CONCLUSION: Prophylactic dosage of antifungal agents (garlicin or low dosage fluconazole) can reduce the incidence of fungal infection in patients with SAP. But once fungal infection occurs, amphotericin B should be used as early as possible if fluconazole is not effective.

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