Published online Feb 15, 2002. doi: 10.3748/wjg.v8.i1.176
Revised: September 23, 2001
Accepted: October 27, 2001
Published online: February 15, 2002
AIM: To study the bioadhesive property of carbomer934 in dog alimentary tract.
METHODS: Carbomer934 and ethylcellulose were radiolabelled with technetium-99 m; and Gastrointestinal emptying rate of materials was measured using the technique of gamma scintigraphy.
RESULTS: After oral administration, the maximum intestinal radioactivity of non-bioadhesive granules and bioadhesive granules were observed in the second hour and the sixth hour respectively. Constants of stomach emptying rate of nonadhesive granules, bioadhesive granulesI and bioadhesive granulesII were 0.774 h-1,0.265 h-1 and 0.321 h-1 respectively on the base of gastric residual amount. Compared to nonadhesive material (ethylcellulose), the migration rate of adhesive material(carbomer934) was remarkably slower in dog alimentary canal.
CONCLUSION: It is concluded that, in the dog, interactions between gastrointestinal mucus layer and adhesive material or nonadhesive material were significantly different. Carbomer934 had stronger in vivo bioadhesive property than ethylcellulose.