Basic Research
Copyright ©The Author(s) 2002. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 2002; 8(1): 176-179
Published online Feb 15, 2002. doi: 10.3748/wjg.v8.i1.176
Study on of bioadhesive property of carbomer934 by a gamma camera in vivo
Jie Fu, Xun Sun, Zhi-Rong Zhang
Jie Fu, Xun Sun, Zhi-Rong Zhang, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
Author contributions: All authors contributed equally to the work.
Supported by the Nation Distinguished Youth Scientific Fund (No. 39925039)
Correspondence to: Zhi-Rong Zhang, Ph.D., West China School of Pharmacy, Sichuan University. Chengdu, 610041, China. zrzzl@mail.sc.cninfo.net
Telephone: +86-28-5501566 Fax: +86-28-5456898
Received: July 19, 2001
Revised: September 23, 2001
Accepted: October 27, 2001
Published online: February 15, 2002
Abstract

AIM: To study the bioadhesive property of carbomer934 in dog alimentary tract.

METHODS: Carbomer934 and ethylcellulose were radiolabelled with technetium-99 m; and Gastrointestinal emptying rate of materials was measured using the technique of gamma scintigraphy.

RESULTS: After oral administration, the maximum intestinal radioactivity of non-bioadhesive granules and bioadhesive granules were observed in the second hour and the sixth hour respectively. Constants of stomach emptying rate of nonadhesive granules, bioadhesive granulesI and bioadhesive granulesII were 0.774 h-1,0.265 h-1 and 0.321 h-1 respectively on the base of gastric residual amount. Compared to nonadhesive material (ethylcellulose), the migration rate of adhesive material(carbomer934) was remarkably slower in dog alimentary canal.

CONCLUSION: It is concluded that, in the dog, interactions between gastrointestinal mucus layer and adhesive material or nonadhesive material were significantly different. Carbomer934 had stronger in vivo bioadhesive property than ethylcellulose.

Keywords: $[Keywords]