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©The Author(s) 1999. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 1999; 5(1): 28-30
Published online Feb 15, 1999. doi: 10.3748/wjg.v5.i1.28
Published online Feb 15, 1999. doi: 10.3748/wjg.v5.i1.28
Experimental research on phospholipids variation of halothane on liver mitochondria
Bo Sui, Yong-De Ma, Department of Anesthesia, General Hospital of Jianan Commanding Area, Jinan 250031, Shandong Province, China
Guang-Ming Zhang, School of Pharmacy, the Second Military Medical University, Shanghai 200433, China
Wei-Feng Yu, Department of Anesthesia, East Liver Surgical Hospital, the Second Military Medical University, Shanghai 200433, China
Xue-Min Wang, Department of Biochemistry, Basic Section, the Second Military Med-ical University, Shanghai 200433, China
Shu-Xiao Liu, Department of Anesthesia, Changhai Hospital, the Second Military Medical University, Shanghai 200433, China
Bo Sui, male, born in 1958 in Shandong Province, graduated from the Second Military Medical University as a postgraduate in 1995, now an attending aesthetist, East Hepatobilliary Surgery Hospital, the Second Military Medical University, Shanghai 200433, having 12 papers published.
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No.94300126.
Correspondence to: Dr. Bo Sui, Department of Anesthesia, General Hospital of Jinan Commanding Area, Jinan 250031,China
Telephone: +8-531-5946536
Received: August 27, 1998
Revised: September 19, 1998
Accepted: October 26, 1998
Published online: February 15, 1999
Revised: September 19, 1998
Accepted: October 26, 1998
Published online: February 15, 1999
Abstract
AIM To study the pathogenesis of hepatotoxicity of halothane.
METHODS The effect of different concentration of halothane and sevoflurane on mitochondrial membrane phospholipids composition of rat liver were analyzed using high performance liquid chromatography (HPLC) technology.
RESULTS Halothane at low concentration could degrade mitochondr ial membrane major phos-pholipids and increase lysophosphatidylcholine.
CONCLUSION The pathogenesis of halothane hepatotoxicity was the phospholipids variation on liver mitochondria.
Keywords: halothane; sevoflurane; liver mitochondria; HPLC; hepatotoxicity