Lu MD, Yin YY, Ren W. Study of portal vein embolization with absolute ethanol injection in cirrhotic rats. World J Gastroenterol 1998; 4(5): 415-417 [PMID: 11819334 DOI: 10.3748/wjg.v4.i5.415]
Corresponding Author of This Article
Dr. Ming-De Lu, Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, Guangdong Province, China
Article-Type of This Article
Original Articles
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Lu MD, Yin YY, Ren W. Study of portal vein embolization with absolute ethanol injection in cirrhotic rats. World J Gastroenterol 1998; 4(5): 415-417 [PMID: 11819334 DOI: 10.3748/wjg.v4.i5.415]
World J Gastroenterol. Oct 15, 1998; 4(5): 415-417 Published online Oct 15, 1998. doi: 10.3748/wjg.v4.i5.415
Study of portal vein embolization with absolute ethanol injection in cirrhotic rats
Ming-De Lu, Yiao-Yu Yin, Wei Ren
Ming-De Lu, Yiao-Yu Yin, Wei Ren, Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, Guangdong Province, China
Ming-De Lu, male, born on 1951-03-25 in Hunan Province, graduated from Sun Yat-Sen University and earned Doctoral Degree (DMSc) from Kyushuo University (Japan), now professor and director of Department of Surgery, majoring hepatobiliary surgery, having 70 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Ming-De Lu, Department of Hepatobiliary Surgery, the First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, Guangdong Province, China
Received: May 6, 1998 Revised: June 23, 1998 Accepted: July 26, 1998 Published online: October 15, 1998
Abstract
AIM: To investigate the effects of portal vein embolization (PVE) with absolute ethanol injection on the cirrhotic livers.
METHODS: Absolute ethanol was injected intraportally into normal and cirrhotic SD rats and the changes of the animals in anatomy, pathology, liver function as well as portal hemodynamics were observed.
RESULTS: At a dose of 0.05mL/ 100g of ethanol, the survival rate was 100% in normal rats compared with 40.9% in cirrhotic rats. PVE in the cirrhotic rats with 0.03 mL/100 g of ethanol, caused significant hypertrophy in non-embolized lobes, mild or moderate damage to the hepatic parenchyma, slight and transient alterations in liver function, portal pressure and portal flow.
CONCLUSION: PVE with absolute ethanol injection in the setting of liver cirrhosis could be safe at an appropriate dose, and precautions aimed at preserving liver function were preferable.
