Xiao L, Zhou HY, Luo ZC, Liu J. Telomeric associations of chromosomes in patients with esophageal squamous cell carcinomas. World J Gastroenterol 1998; 4(3): 231-233 [PMID: 11819283 DOI: 10.3748/wjg.v4.i3.231]
Corresponding Author of This Article
Lin Xiao, Institute of Oncology, West China University of Medical Sciences, Chendu 610041, Sichuan Province, China
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World J Gastroenterol. Jun 15, 1998; 4(3): 231-233 Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.231
Telomeric associations of chromosomes in patients with esophageal squamous cell carcinomas
Lin Xiao, Hong-Yuan Zhou, Zhong-Cheng Luo, Jun Liu
Lin Xiao, Hong-Yuan Zhou, Jun Liu, Institute of Oncology, West China University of Medical Sciences, Chendu 610041, Sichuan Province, China
Zhong-Cheng Luo, Department of Paediatrics, Queen Mary Hospital, the University of Hong Kong, Hong Kong
Lin Xiao, female, was born on Dec. 30, 1962, Chendu, Sichuan Province. Master of Medical Sciences, graduated from Institute of Oncology, West China University of Medical Sciences, having 10 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Lin Xiao, Institute of Oncology, West China University of Medical Sciences, Chendu 610041, Sichuan Province, China
Telephone: +86-28-5501282
Received: November 25, 1997 Revised: February 25, 1998 Accepted: April 20, 1998 Published online: June 15, 1998
Abstract
AIM: To investigate the role of telomeric association in the development of esophageal cancer.
METHODS: Using chromosome R banding technique,telomeric association of chromosome in peripheral blood lymphocytes from 16 untreated patients with esophageal squamous cell carcinoma were observed and 16 healthy adults served as controls.
RESULTS: The teloemeric association frequencies of cell and chromosomes were significantly higher than those of controls (χ2 = 9.56, P < 0.01), but its distribution on the chromosome showed no significant difference (χ2 = 1.01, P > 0.05) between the two groups.
CONCLUSION: Chromosomal instability can be initiated by telomeric associations, and sequential chromosome analysis can aid the understanding of the tumor occurrence and progression.
